Evidence map›Paper›PMID 29623875›Full record

ArticleTuberculosis (Edinburgh, Scotland)2018

Use of a leukocyte-targeted peptide probe as a potential tracer for imaging the tuberculosis granuloma.

Landon W Locke, Shankaran Kothandaraman, Michael Tweedle, Sarah Chaney, Daniel J Wozniak, Larry S Schlesinger

Abstract read
In one paragraph

Article in Tuberculosis (Edinburgh, Scotland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Evaluation of Peptide-Based Probes towardACS infectious diseases · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Landon W LockeDepartment of Microbial Infection and Immunity, Center for Microbial Interface Biology, 793 Biomedical Research Tower, 460 W. 12th Avenue, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA. Electronic address: Landon.Locke@osumc.edu.
Shankaran KothandaramanDepartment of Radiology, The Wright Center for Innovation in Biomedical Imaging, Martha Morehouse Medical Plaza, 2050 Kenny Road, The Ohio State University, Columbus, OH 43221, USA. Electronic address: Shankaran.Kothandaraman@osumc.edu.
Michael TweedleDepartment of Radiology, The Wright Center for Innovation in Biomedical Imaging, Martha Morehouse Medical Plaza, 2050 Kenny Road, The Ohio State University, Columbus, OH 43221, USA. Electronic address: Michael.Tweedle@osumc.edu.
Sarah ChaneyDepartment of Veterinary Biosciences, College of Veterinary Medicine, Ohio State University, Columbus, OH, USA.
Daniel J WozniakDepartment of Microbial Infection and Immunity, Center for Microbial Interface Biology, 793 Biomedical Research Tower, 460 W. 12th Avenue, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA. Electronic address: Daniel.Wozniak@osumc.edu.
Larry S SchlesingerDepartment of Microbial Infection and Immunity, Center for Microbial Interface Biology, 793 Biomedical Research Tower, 460 W. 12th Avenue, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA; Texas Biomedical Research Institute, 7620 NW Loop 410, San Antonio, TX 78227, USA. Electronic address: LSchlesinger@txbiomed.org.
Center for Innovation · USThe Ohio State University Wexner Medical Center · USTexas Biomedical Research Institute · USThe Ohio State University · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
MOLECULAR MECHANISMS OF LUNG INFLAMMATIONT32HL007946 · NHLBI · OHIO STATE UNIVERSITY · PI WEWERS, MARK DAMIAN · 2000 to 2017
$3.1M
NCI NIH HHS P30 CA013148NCI NIH HHS P30 CA016058NHLBI NIH HHS T32 HL007946
6 · The paper itself

Abstract

Granulomas are the histopathologic hallmark of tuberculosis (TB), both in latency and active disease. Diagnostic and therapeutic strategies that specifically target granulomas have not been developed. Our objective is to develop a probe for imaging relevant immune cell populations infiltrating the granuloma. We report the binding specificity of Cyanine 3 (Cy3)-labeled cFLFLFK-PEG

Indexed as

Microscopy, ConfocalAdministration, IntravenousAnimalsDisease Models, AnimalFemaleFluorescent DyesGranuloma, Respiratory TractHost-Pathogen InteractionsHumansLatent TuberculosisLungMacrophagesMice, Inbred C57BLMycobacterium tuberculosisNeutrophilsOligopeptidesFluorescent DyesFPR1 protein, humanOligopeptidesReceptors, Formyl PeptideFPR1GranulomaInfection imagingMycobacterium tuberculosisPeptide probePhagocytes

Identifiers

PMID29623875
PMCPMC6014630
OpenAlexW2783026168

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.