Evidence map›Paper›PMID 29623748›Full record

ArticleInfectious diseases (London, England)2018

Neisseria meningitidis disease-associated clones in Amazonas State, Brazil.

Luciete A Silva, Beatriz Coronato, Jessica Schlackman, Jane W Marsh, Chinelo Ezeonwuka, Andréia C L Fernandes, Victor C Souza, Lirna S da Silva, Elaine F Q de Amorim, Felipe G Naveca and 7 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Infectious diseases (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Epidemiological profile ofAccess microbiology · 2020
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Luciete A Silvaa Laboratory of Microbial Diversity of Importance to Health and Laboratory of Communicable Disease Ecology , Leônidas & Maria Deane Institute, FIOCRUZ , Manaus , Brazil.
Beatriz Coronatob Laboratory of Epidemiology and Molecular Systematics , Oswaldo Cruz Institute, FIOCRUZ , Rio de Janeiro , Brazil.
Jessica Schlackmanc Infectious Diseases Epidemiology Research Unit , University of Pittsburgh School of Medicine and Graduate School of Public Health , Pittsburgh , PA , USA.
Jane W Marshc Infectious Diseases Epidemiology Research Unit , University of Pittsburgh School of Medicine and Graduate School of Public Health , Pittsburgh , PA , USA.
Chinelo Ezeonwukac Infectious Diseases Epidemiology Research Unit , University of Pittsburgh School of Medicine and Graduate School of Public Health , Pittsburgh , PA , USA.
Andréia C L Fernandesb Laboratory of Epidemiology and Molecular Systematics , Oswaldo Cruz Institute, FIOCRUZ , Rio de Janeiro , Brazil.
Victor C Souzaa Laboratory of Microbial Diversity of Importance to Health and Laboratory of Communicable Disease Ecology , Leônidas & Maria Deane Institute, FIOCRUZ , Manaus , Brazil.
Lirna S da Silvaa Laboratory of Microbial Diversity of Importance to Health and Laboratory of Communicable Disease Ecology , Leônidas & Maria Deane Institute, FIOCRUZ , Manaus , Brazil.
Elaine F Q de Amorima Laboratory of Microbial Diversity of Importance to Health and Laboratory of Communicable Disease Ecology , Leônidas & Maria Deane Institute, FIOCRUZ , Manaus , Brazil.
Felipe G Navecaa Laboratory of Microbial Diversity of Importance to Health and Laboratory of Communicable Disease Ecology , Leônidas & Maria Deane Institute, FIOCRUZ , Manaus , Brazil.
Bernardino C de Albuquerqued Department of Epidemiological Surveillance and Central Laboratory , Foundation of Health Surveillance of Amazonas , Manaus , AM , Brazil.
Alcirene Amarald Department of Epidemiological Surveillance and Central Laboratory , Foundation of Health Surveillance of Amazonas , Manaus , AM , Brazil.
Ana L S Souzad Department of Epidemiological Surveillance and Central Laboratory , Foundation of Health Surveillance of Amazonas , Manaus , AM , Brazil.
Filipe A Carvalho-Costab Laboratory of Epidemiology and Molecular Systematics , Oswaldo Cruz Institute, FIOCRUZ , Rio de Janeiro , Brazil.
Mustapha M Mustaphac Infectious Diseases Epidemiology Research Unit , University of Pittsburgh School of Medicine and Graduate School of Public Health , Pittsburgh , PA , USA.
Lee H Harrisonc Infectious Diseases Epidemiology Research Unit , University of Pittsburgh School of Medicine and Graduate School of Public Health , Pittsburgh , PA , USA.
David E Barrosob Laboratory of Epidemiology and Molecular Systematics , Oswaldo Cruz Institute, FIOCRUZ , Rio de Janeiro , Brazil.

Funding

Real-Time PCR for Diagnosis of Culture-Negative Bacterial Meningitis in S?o PauloD43TW006592 · FIC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARRISON, LEE H · 2004 to 2013
$1.7M
FIC NIH HHS D43 TW006592
6 · The paper itself

Abstract

backgroundThe aim of this study is to describe the molecular epidemiology of Neisseria meningitidis invasive disease before the introduction of serogroup C conjugate vaccine in Amazonas State in 2010.

methodsMeningococcal disease reported cases were investigated in Amazonas State during the period 2000-2010. N. meningitidis isolates (n = 196) recovered from patients were genotyped by multilocus sequence typing (MLST) and sequencing of porB, porA, fetA, fHbp and penA. Antimicrobial susceptibility was determined using E-test.

resultsIn the study period, 948 cases were reported; the incidence was 2.8 for the entire state and 4.8 per 100,000 in the capital of Manaus. Most meningococcal disease was caused by N. meningitidis belonging to ST-32 (72%; 141/196) or ST-103 (21%; 41/196) clonal complexes. Capsular switching (B→C) was suggested within clonal complex (cc) 32. There were 6 (3%; 6/196) strains with intermediate susceptibility to penicillin and a single strain was resistant to rifampicin. Since 2007, serogroup C strains belonging to the cc103 have predominated and case-fatality has increased.

conclusionWe demonstrate a high rate of meningococcal disease in Amazonas State, where, like other parts of Brazil, serogroup C replaced serogroup B during 2000s. These data serve as a baseline to measure impact of serogroup C conjugate vaccine introduction in 2010. This study emphasizes the need for enhanced surveillance to monitor changes in meningococcal disease trends following the introduction of meningococcal vaccines.

Indexed as

Anti-Bacterial AgentsAntigens, BacterialBrazilDNA, BacterialGenes, BacterialGenotypeHumansMeningococcal InfectionsMicrobial Sensitivity TestsMicrobial ViabilityMolecular EpidemiologyMultilocus Sequence TypingNeisseria meningitidisSerogroupAnti-Bacterial AgentsAntigens, BacterialDNA, BacterialAmazonasMeningococcal diseaseMLST clonesNeisseria meningitidisSerogroup C conjugate vaccine

Identifiers

PMID29623748
PMCPMC6120802

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