ArticleEnvironmental science and pollution research international2018
The association between serum copper concentrations and cardiovascular disease risk factors in children and adolescents in NHANES.
Article in Environmental science and pollution research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- Association Between Serum Essential Metal Elements and Blood Pressure in Children: A Cohort Study.Cardiovascular toxicology · 2025Article
- Article
- High Copper Intake Is Associated with Decreased Likelihood of Abdominal Aortic Calcification in Middle-Aged and Older US Adults.Biological trace element research · 2024Article
- Relationship between coronary artery disease with dyslipidaemia and trace mineral intake: a cross-sectional analysis of the Shika study.Journal of nutritional science · 2024Article
- Association of heavy metals exposure with lower blood pressure in the population aged 8-17 years: a cross-sectional study based on NHANES.Frontiers in public health · 2024Article
- A novel bioaccessibility-based probabilistic risks assessment of potentially toxic elements (PTEs) in earthworm.Frontiers in pharmacology · 2024Article
- How Do Minerals, Vitamins, and Intestinal Microbiota Affect the Development and Progression of Heart Disease in Adult and Pediatric Patients?Nutrients · 2023Review
- Technical guidelines for risk assessment of heavy metals in traditional Chinese medicines.Chinese medicine · 2023Review
- Copper homeostasis and copper-induced cell death in the pathogenesis of cardiovascular disease and therapeutic strategies.Cell death & disease · 2023Review
- Copper/Zinc Ratio in Childhood and Adolescence: A Review.Metabolites · 2023Review
- Trace Elements Open a New Direction for the Diagnosis of Atherosclerosis.Reviews in cardiovascular medicine · 2023Review
- Gene-environment interaction analysis of redox-related metals and genetic variants with plasma metabolic patterns in a general population from Spain: The Hortega Study.Redox biology · 2022Article
- Total cholesterol: a potential mediator of the association between exposure to acrylamide and hypertension risk in adolescent females.Environmental science and pollution research international · 2022Article
- Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study.Nutrients · 2021Article
- The Association between Zinc and Copper Circulating Levels and Cardiometabolic Risk Factors in Adults: A Study of Qatar Biobank Data.Nutrients · 2021Article
- Exposure to metal mixtures in relation to blood pressure among children 5-7 years old: An observational study in Bangladesh.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- Associations of Plasma Copper, Magnesium, and Calcium Levels with Blood Pressure in Children: a Cross-sectional Study.Biological trace element research · 2021Article
- The association between serum copper concentrations and elevated blood pressure in US children and adolescents: National Health and Nutrition Examination Survey 2011-2016.BMC cardiovascular disorders · 2021Article
- Geographical origin differentiation of Chinese Angelica by specific metal element fingerprinting and risk assessment.Environmental science and pollution research international · 2020Article
- The Causal Effects of Blood Iron and Copper on Lipid Metabolism Diseases: Evidence from Phenome-Wide Mendelian Randomization Study.Nutrients · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Copper is an essential element in human beings, alterations in serum copper levels could potentially have effect on human health. To date, no data are available regarding how serum copper affects cardiovascular disease (CVD) risk factors in children and adolescents. We examined the association between serum copper levels and CVD risk factors in children and adolescents. We analyzed data consisting of 1427 subjects from a nationally representative sample of the US population in the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2014. The CVD risk factors included total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, fasting glucose, glycohemoglobin, fasting insulin, and blood pressure. Multivariate and generalized linear regressions were performed to investigate associations adjusted for age, gender, ethnicity, poverty:income ratio (PIR), BMI, energy intake, and physical activity. We found significant associations between serum copper and total cholesterol (coefficient = 0.132; 95% CI 0.081, 0.182; P for trend < 0.001), glycohemoglobin (coefficient = 0.044; 95% CI 0.020, 0.069; P < 0.001), and fasting insulin (coefficient = 0.730; 95% CI 0.410, 1.050; P < 0.001) among the included participants. Moreover, in the generalized linear models, subjects with the highest copper levels demonstrated a 0.83% (95% CI 0.44%, 1.24%) greater increase in serum total cholesterol (p for trend < 0.001) when compared to participants with the lowest copper concentrations. Our results provide the first epidemiological evidence that serum copper concentrations are associated with total cholesterol concentrations in children and adolescents. However, the underlying mechanisms still need further exploration.
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