Evidence map›Paper›PMID 29623478›Full record

ArticleCellular and molecular neurobiology2018

Continued Tumor Reduction of Metastatic Pheochromocytoma/Paraganglioma Harboring Succinate Dehydrogenase Subunit B Mutations with Cyclical Chemotherapy.

Irfan Jawed, Margarita Velarde, Roland Därr, Katherine I Wolf, Karen Adams, Aradhana M Venkatesan, Sanjeeve Balasubramaniam, Marianne S Poruchynsky, James C Reynolds, Karel Pacak and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. A novel germline (c.314T>A)Frontiers in endocrinology · 2025
    Review
  5. Review
  6. [Advance in HIF expression and immune microenvironment in pseudohypoxic HNPGL].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Pheochromocytoma: a changing perspective and current concepts.Therapeutic advances in endocrinology and metabolism · 2023
    Review
  16. Article
  17. New Biology of Pheochromocytoma and Paraganglioma.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2022
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Irfan JawedMedical Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Margarita VelardeMedical Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Roland DärrSection on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA.
Katherine I WolfSection on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA.
Karen AdamsSection on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA.
Aradhana M VenkatesanSection of Abdominal Imaging, Department of Diagnostic Radiology, MD Anderson Cancer Center, Houston, TX, 77030, USA.
Sanjeeve BalasubramaniamMedical Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Marianne S PoruchynskyMedical Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
James C ReynoldsNuclear Medicine Division, Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, 20892, USA.
Karel PacakSection on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA. karel@mail.nih.gov.
Tito FojoMedical Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Eunice Kennedy Shriver National Institute of Child Health and Human Development · USNational Cancer Institute · USNational Institutes of Health · USNational Institutes of Health Clinical Center · USThe University of Texas MD Anderson Cancer Center · US

Funding

Diagnosis, Pathophysiology And Molecular Biology of Pheochromocytoma and ParagangliomaZIAHD008735 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI PACAK, KAREL · 2009 to 2024
$28.4M
Intramural NIH HHS ZIA HD008735
6 · The paper itself

Abstract

Patients harboring germline mutations in the succinate dehydrogenase complex subunit B (SDHB) gene present with pheochromocytomas and paragangliomas (PPGL) that are more likely malignant and clinically aggressive. The combination chemotherapy cyclophosphamide, vincristine, and dacarbazine (CVD) was retrospectively evaluated in patients with SDHB-associated metastatic PPGL.Query Twelve metastatic PPGL patients harboring SDHB mutations/polymorphisms with undetectable SDHB immunostaining were treated with CVD. CVD therapy consisted of 750 mg/m

Indexed as

AdolescentAdultFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedMutationNeoplasm MetastasisParagangliomaPheochromocytomaPositron-Emission TomographySuccinate DehydrogenaseTreatment OutcomeYoung AdultFluorodeoxyglucose F18SDHB protein, humanSuccinate DehydrogenaseCyclophosphamideDacarbazinePheochromocytoma/paragangliomaSuccinate dehydrogenaseVincristine

Identifiers

PMID29623478
PMCPMC5976545
OpenAlexW2796197111

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.