ArticleVirchows Archiv : an international journal of pathology2018
Misses and near misses in diagnosing nodular fasciitis and morphologically related reactive myofibroblastic proliferations: experience of a referral center with emphasis on frequency of USP6 gene rearrangements.
Article in Virchows Archiv : an international journal of pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 46 citations in OpenAlex.
- Intra-Abdominal Sporadic Desmoid Tumors with CanonicalInternational journal of molecular sciences · 2026Article
- Mandibular Inflammatory Myofibroblastic Tumors: A Literature Review with a New Case Presentation.Current oncology (Toronto, Ont.) · 2026Review
- Solitary fibrous tumor: an updated review.Journal of pathology and translational medicine · 2026Article
- Natural course of patients diagnosed with nodular fasciitis.BMC musculoskeletal disorders · 2025Article
- Article
- GLUT-1 expression is helpful to distinguish myxofibrosarcoma from nodular fasciitis.Histology and histopathology · 2023Article
- Case report: Large-size intramuscular nodular fasciitis, a challenging histopathologic diagnosis confirmed by molecular detection of USP6 gene rearrangement: Case report and literature review.Pathology oncology research : POR · 2023Review
- Nodular fasciitis: a comprehensive, time-correlated investigation of 17 cases.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021Article
- Nodular fasciitis of the breast: clinicopathologic and molecular characterization with identification of novel USP6 fusion partners.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021Article
- Recurrent FOS rearrangement in proliferative fasciitis/proliferative myositis.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021Article
- MR imaging features and a redefinition of the classification system for nodular fasciitis.Medicine · 2020Article
- [Fluorescence in situ hybridization for the diagnosis of soft-tissue and bone tumors].Der Pathologe · 2020Review
- Papillary thyroid carcinoma with prominent myofibroblastic stromal component: clinicopathologic, immunohistochemical and next-generation sequencing study of seven cases.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020Article
- Diagnostic Differences in Expert Second-Opinion Consultation Cases at a Tertiary Sarcoma Center.Sarcoma · 2020Article
- Ubiquitin-specific Peptidase 6 (Cancer genomics & proteomicsReview
- Multiple Perifollicular Fibrous Papules of the Neck Mimicking Verruca Plana in an Elderly Woman: A Case Report.Case reports in dermatologyArticle
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Although harmless, reactive and benign neoplastic myo-/fibroblastic proliferations represent a diagnostic challenge in routine surgical pathology practice as reflected by their frequency among consultation cases. In addition to resembling each other, the prototypical nodular fasciitis (NF) and NF-like lesions can be mistaken for low-grade or aggressive sarcomas. USP6 translocation was reported recently as the molecular driver and potential diagnostic marker of NF. We reviewed 71 lesions with a diagnosis of NF (n = 48) or NF-like myofibroblastic proliferations (n = 23) and screened them for USP6 translocation by fluorescence in situ hybridization (FISH). Only one third of NFs were correctly diagnosed by submitting pathologists while one third was initially judged as malignant. NF was mentioned in the differential diagnosis in only half of the cases. A high Ki67/mitotic index, misleading immunohistochemistry (false-positive h-caldesmon), and unusual sites/circumscription were main causes behind overdiagnosis as malignant. FISH analysis revealed USP6 translocation in 74.4% of NF cases. None of the reactive/reparative myofibroblastic proliferations showed USP6 translocation. NF is still significantly misdiagnosed by general surgical pathologists, with a higher tendency toward overdiagnosis of malignancy. Inclusion of NF in the differential diagnosis of any fibromyxoid soft tissue lesion and awareness of its diverse morphology are mandatory to avoid misdiagnoses with the risk of disastrous overtreatment. In the appropriate clinicopathological context, USP6 gene translocation is a valuable adjunct for diagnosis of NF, particularly in limited biopsies. Absence of the USP6 gene translocation in NF-like reparative pseudosarcomatous myofibroblastic proliferations underlines their reactive nature and distinguishes them from NF which is currently considered a benign neoplasm with a self-limiting "transient" growth phase.
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