ReviewGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2018
Current perspectives on corneal collagen crosslinking (CXL).
Review in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04160338 (A Specular Microscopic Study of Corneal Endothelium After Accelerated Corneal Collagen Cross Linking), which is not on this map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Specular Microscopic Study of Corneal Endothelium After Accelerated Corneal Collagen Cross Linking
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Corneal cross-linking for infectious keratitis of various causes: an umbrella review.BMC ophthalmology · 2025Pooled it
- Eight-year results of LASIK with or without combined accelerated crosslinking in highly myopic eyes.Journal of cataract and refractive surgery · 2026Trial
- A comparison of conventional and accelerated corneal crosslinking: corneal epithelial remodeling and in vivo confocal microscopy analysis.International ophthalmology · 2024Trial
- The efficiency and safety of oxygen-supplemented accelerated transepithelial corneal cross-linking.International ophthalmology · 2021Trial
- Sociodemographic determinants of disease severity in a public healthcare system : Evidence from keratoconus patients in Austria.Wiener klinische Wochenschrift · 2026Article
- Assessment of choroidal vascularity and thickness after corneal crosslinking treatment in keratoconus.BMC ophthalmology · 2026Article
- One-Year Visual, Refractive, Tomographic, and Aberrometric Outcomes of Repeat Corneal Collagen Crosslinking in Eyes with Progressive Keratoconus.Beyoglu eye journal · 2026Article
- Impact of Corneal Crosslinking on Endothelial and Biomechanical Parameters in Keratoconus.Journal of clinical medicine · 2025Article
- A Review of Keratoconus Cross-Linking Treatment Methods.Journal of clinical medicine · 2025Review
- Comparison of the Depth of the Stromal Demarcation Line and Clinical Outcomes in Corneal Crosslinking Treatment with Hydroxypropyl Methylcellulose-Based and Vitamin E-TPGS-Based Riboflavin Solutions.Beyoglu eye journal · 2025Article
- Progressive Keratoconus Treatment with Transepithelial Two-Step Phototherapeutic Keratectomy Combined with Corneal Crosslinking (CXL): Clinical Outcomes and Postoperative Management Including Potential Complications of the Modified Athens Protocol Designed for US-Approved Excimer Laser Specifications.Journal of clinical medicine · 2024Article
- Influence of Dextran Solution and Corneal Collagen Crosslinking on Corneal Biomechanical Parameters Evaluated by Corvis ST In Vitro.Bioengineering (Basel, Switzerland) · 2024Article
- The in vitro effect riboflavin combined with or without UVA in Acanthamoeba castellanii.Scientific reports · 2024Article
- The impact of interrupted corneal collagen crosslinking (CXL) treatment.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- A unique and biocompatible corneal collagen crosslinking in vivo.Scientific reports · 2024Article
- Quantitative assessment of corneal biomechanical changes in vivo after photorefractive intrastromal corneal cross-linking using optical coherence elastography.Quantitative imaging in medicine and surgery · 2024Article
- Accelerated corneal cross-linking (18mW/cm2 for 5 min) with HPMC-riboflavin in progressive keratoconus - 5 years follow-up.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Transepithelial Accelerated Crosslinking for Progressive Keratoconus: A Critical Analysis of Medium-Term Treatment Outcomes.Clinical ophthalmology (Auckland, N.Z.) · 2024Article
- The effect of accelerated pulsed high-fluence corneal cross-linking on corneal endothelium; a prospective specular microscopy study.BMC ophthalmology · 2023Article
- Severe Complications after Corneal Collagen Cross-Linking (CXL).Klinische Monatsblatter fur Augenheilkunde · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Corneal collagen crosslinking has revolutionized the treatment of keratoconus and post-refractive corneal ectasia in the past decade. Corneal crosslinking with riboflavin and ultraviolet A is proposed to halt the progression of keratectasia. In the original "Conventional Dresden Protocol" (C-CXL), the epithelium is removed prior to the crosslinking process to facilitate better absorption of riboflavin into the corneal stroma. Studies analyzing its short- and long-term outcomes revealed that although there are inconsistencies as to the effectiveness of this technique, the advantages prevail over the disadvantages. Therefore, corneal crosslinking (CXL) is widely used in current practice to treat keratoconus. In an attempt to improve the visual and topographical outcomes of C-CXL and to minimize time-related discomfort and endothelial-related side effects, various modifications such as accelerated crosslinking and transepithelial crosslinking methods have been introduced. The comparison of outcomes of these modified techniques with C-CXL has also returned contradictory results. Hence, it is difficult to clearly identify an optimal procedure that can overcome issues associated with the CXL. This review provides an up-to-date analysis on clinical and laboratory findings of these popular crosslinking protocols used in the treatment of keratoconus. It is evident from this review that in general, these modified techniques have succeeded in minimizing the immediate complications of the C-CXL technique. However, there were contradictory viewpoints regarding their effectiveness when compared with the conventional technique. Therefore, these modified techniques need to be further investigated to arrive at an optimal treatment option for keratoconus.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.