Evidence map›Paper›PMID 29623462›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2018

Long-term follow-up of lamellar macular holes and pseudoholes over at least 5 years.

K Purtskhvanidze, L Balken, T Hamann, L Wöster, C von der Burchard, J Roider, Felix Treumer

Abstract read
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In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
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  5. Article
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  8. Primary Lamellar Macular Holes: To Vit or Not to Vit.Journal of clinical medicine · 2022
    Review
  9. Review
  10. Improving morphological outcome in lamellar macular hole surgery by using highly concentrated autologous platelet-rich plasma.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. [Biomarkers in full-thickness and lamellar defects of the macula].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2021
    Review
  15. Article
  16. Angulation of the inner nuclear layer as an indicator of the severity of macular pseudohole.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021
    Article
  17. Review
  18. Article
  19. Results of lamellar macular hole-associated epiretinal proliferation embedding technique for the treatment of degenerative lamellar macular hole.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

K PurtskhvanidzeDepartment of Ophthalmology, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, building 25, 24105, Kiel, Germany.
L BalkenDepartment of Ophthalmology, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, building 25, 24105, Kiel, Germany.
T HamannDepartment of Ophthalmology, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, building 25, 24105, Kiel, Germany.
L WösterDepartment of Ophthalmology, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, building 25, 24105, Kiel, Germany.
C von der BurchardDepartment of Ophthalmology, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, building 25, 24105, Kiel, Germany.
J RoiderDepartment of Ophthalmology, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, building 25, 24105, Kiel, Germany.
Felix TreumerDepartment of Ophthalmology, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, building 25, 24105, Kiel, Germany. felixtreumer@googlemail.com.ORCID http://orcid.org/0000-0003-2664-7040

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess morphological and functional changes of lamellar macular holes and pseudoholes with or without vitrectomy and membrane peeling with at least 5 years follow-up.

methodsRetrospective study of 73 eyes with lamellar macular hole (LH, n = 28), macular pseudohole (PH, n = 31), and pseudohole with cleaved edges (cleavedPH, n = 14). Forty-six eyes were merely observed without vitreoretinal intervention (observation group), and 27 eyes underwent vitrectomy with membrane peeling (vitrectomy group). Outcome measures were best corrected visual acuity (BCVA) and morphological retinal parameters evaluated with optical coherence tomography (TD-OCT and SD-OCT).

resultsMean follow-up was 8.3 years (5-12); mean age was 67 years (46-84). In the observation group, median BCVA (logMAR) at first exam was 0.2 (LH), 0.1 (PH), 0.2 (cleavedPH) and at last exam 0.3 (LH, p = 0.02), 0.2 (PH), 0.15 (cleavedPH). In the vitrectomy group, median BCVA at first exam was 0.4 (LH), 0.3 (PH), 0.25 (cleavedPH); before vitrectomy BCVA was 0.5 (LH), 0.35 (PH), 0.35 (cleavedPH); and at last exam BCVA increased to 0.3 (LH), 0.2 (PH, p < 0.05), 0.1 (cleavedPH, p < 0.05). At last exam, BCVA of LH was significantly worse compared to PH and cleavedPH. In the observation group, 6 of 29 eyes with PH or cleavedPH showed a spontaneous resolution of the epiretinal membrane with improvement of the foveal contour. Nine of 16 eyes with LH and 2/20 eyes with PH presented lamellar hole-associated epiretinal proliferation (LHEP) in SD-OCT.

conclusionsLH, PH, and cleavedPH are often stable over a very long time. LH tends to worse visual function compared to PH and cleavedPH. A spontaneous separation of epiretinal membranes in the long-term is not uncommon. Vitreoretinal intervention should be considered in cases with significant visual loss or functional and morphological progression.

Indexed as

ForecastingAgedAged, 80 and overBasement MembraneDiagnosis, DifferentialDisease ProgressionEpiretinal MembraneFemaleFollow-Up StudiesHumansMacula LuteaMaleMiddle AgedPrognosisRetinal PerforationsRetrospective StudiesLamellar macular holeMacular pseudoholeMembrane peelingOptical coherence tomographyVitrectomy

Identifiers

PMID29623462

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.