ArticleBrain structure & function2018
Frontal cortical control of posterior sensory and association cortices through the claustrum.
Article in Brain structure & function, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Human lesions and animal studies link the claustrum to perception, salience, sleep and pain.Brain : a journal of neurology · 2022Pooled it
- Human claustrum neurons encode uncertainty and prediction errors during aversive learning.Nature neuroscience · 2026Article
- Anterior cingulate cortex activation of claustrum projection neuron subtypes is enhanced by alcohol.Neuropharmacology · 2026Article
- New functional insights from the monkey claustrum.National science review · 2026Review
- The human claustrum supports cognitive networks for externally and internally driven task demands.PLoS biology · 2026Article
- A comprehensive and reliable protocol for manual segmentation of the human claustrum using high-resolution MRI.Brain structure & function · 2025Article
- The Role of the Claustrum in Parkinson's Disease and Vascular Parkinsonism: A Matter of Network?Life (Basel, Switzerland) · 2025Review
- Resting-state functional connectivity of the marmoset claustrum.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Pathological claustrum activity drives aberrant cognitive network processing in human chronic pain.Current biology : CB · 2024Article
- Reduced Reward Processing in Schizophrenia: A Comprehensive EEG Event-Related Oscillation Study.Brain topography · 2024Article
- Pathological claustrum activity drives aberrant cognitive network processing in human chronic pain.bioRxiv : the preprint server for biology · 2023Article
- Regional and cell-type-specific afferent and efferent projections of the mouse claustrum.Cell reports · 2023Article
- The mouse claustrum synaptically connects cortical network motifs.Cell reports · 2022Article
- A role for the claustrum in cognitive control.Trends in cognitive sciences · 2022Review
- Layer 6A Pyramidal Cell Subtypes Form Synaptic Microcircuits with Distinct Functional and Structural Properties.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Article
- The functional connectivity and neuropsychology underlying mental planning operations: data from the digital clock drawing test.Frontiers in aging neuroscience · 2022Article
- The mystery of claustral neural circuits and recent updates on its role in neurodegenerative pathology.Behavioral and brain functions : BBF · 2021Review
- Article
- The claustrum of the sheep and its connections to the visual cortex.Journal of anatomy · 2021Article
Corrections and comments
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2 authors.
Funding
Abstract
The claustrum is a telencephalic gray matter nucleus that is richly interconnected with the neocortex. This structure subserves top-down executive functions that require frontal cortical control of posterior cortical regions. However, functional anatomical support for the claustrum allowing for long-range intercortical communication is lacking. To test this, we performed a channelrhodopsin-assisted long-circuit mapping strategy in mouse brain slices. We find that anterior cingulate cortex input to the claustrum is transiently amplified by claustrum neurons that, in turn, project to parietal association cortex or to primary and secondary visual cortices. Additionally, we observe that claustrum drive of cortical neurons in parietal association cortex is layer-specific, eliciting action potential generation briefly in layers II/III, IV, and VI but not V. These data are the first to provide a functional anatomical substrate through claustrum that may underlie top-down functions, such as executive attention or working memory, providing critical insight to this most interconnected and enigmatic nucleus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.