Evidence map›Paper›PMID 29623376›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2018

Trifunctional PSMA-targeting constructs for prostate cancer with unprecedented localization to LNCaP tumors.

James Kelly, Alejandro Amor-Coarasa, Shashikanth Ponnala, Anastasia Nikolopoulou, Clarence Williams, David Schlyer, Yize Zhao, Dohyun Kim, John W Babich

Abstract read
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 77 citations in OpenAlex.

  1. Article
  2. Review
  3. Tailored Reaction Conditions and Automated Radiolabeling of [International journal of molecular sciences · 2025
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  5. Biodistribution and dosimetry of [European journal of nuclear medicine and molecular imaging · 2025
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  6. JHU-2545 preferentially shields salivary glands and kidneys during PSMA-targeted imaging.European journal of nuclear medicine and molecular imaging · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Preclinical Evaluation of a New Series of Albumin-BindingMolecules (Basel, Switzerland) · 2023
    Article
  15. Targeted Alpha-Particle Therapy: A Review of Current Trials.International journal of molecular sciences · 2023
    Review
  16. [European journal of nuclear medicine and molecular imaging · 2023
    Article
  17. Recent Advances inInternational journal of molecular sciences · 2023
    Review
  18. Article
  19. Preclinical investigations using [European journal of nuclear medicine and molecular imaging · 2022
    Article
  20. Advances in PSMA theranostics.Translational oncology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

James KellyDivision of Radiopharmaceutical Sciences and MI3, Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
Alejandro Amor-CoarasaDivision of Radiopharmaceutical Sciences and MI3, Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
Shashikanth PonnalaDivision of Radiopharmaceutical Sciences and MI3, Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
Anastasia NikolopoulouDivision of Radiopharmaceutical Sciences and MI3, Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
Clarence WilliamsDivision of Radiopharmaceutical Sciences and MI3, Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
David SchlyerBrookhaven National Laboratory, Upton, NY, USA.
Yize ZhaoDivision of Biostatistics and Epidemiology, Department of Healthcare Policy and Research, Weill Cornell Medicine, New York, NY, USA.
Dohyun KimCitigroup Biomedical Imaging Center, Weill Cornell Medicine, New York, NY, USA.
John W BabichDivision of Radiopharmaceutical Sciences and MI3, Department of Radiology, Weill Cornell Medicine, New York, NY, USA. job2060@med.cornell.edu.
Cornell University · USWeill Cornell Medicine · USBrookhaven National Laboratory · USCitigroup · USImaging Center · US

Funding

NIH HHS UL1TR00457
6 · The paper itself

Abstract

purposeTreatment of late-stage prostate cancer by targeted radiotherapeutics such as

methodsLigands incorporating a triazolylphenylurea-containing PSMA-targeting group, an N

resultsPSMA affinity was high (IC

conclusionsThe high tumor uptake achieved with these trifunctional ligands predicts larger (up to 4×) doses delivered to the tumor than can be achieved with

Indexed as

AnimalsAntigens, SurfaceCell Line, TumorCell Transformation, NeoplasticGlutamate Carboxypeptidase IIHumansMaleMiceMolecular Targeted TherapyProstatic NeoplasmsRadiometryTissue DistributionAntigens, SurfaceFOLH1 protein, humanGlutamate Carboxypeptidase IIAlbuminPharmacokineticsProstate cancerPSMATargeted radioligand therapy

Identifiers

PMID29623376
OpenAlexW2795555192

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.