ArticleOptica2017
Focusing light inside scattering media with magnetic-particle-guided wavefront shaping.
Article in Optica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 62 citations in OpenAlex.
- Optimizing fluorescence imaging through scattering media using structured light-assisted wavefront shaping.iScience · 2025Article
- Optical focusing into scattering media via iterative time reversal guided by absorption nonlinearity.Nature communications · 2025Article
- Threading light through dynamic complex media.Nature photonics · 2025Article
- Performance enhancement in wavefront shaping of multiply scattered light: a review.Journal of biomedical optics · 2024Review
- Wavefront shaping: A versatile tool to conquer multiple scattering in multidisciplinary fields.Innovation (Cambridge (Mass.)) · 2022Review
- Neurophotonic tools for microscopic measurements and manipulation: status report.Neurophotonics · 2022Article
- Focusing light into scattering media with ultrasound-induced field perturbation.Light, science & applications · 2021Article
- Memory effect assisted imaging through multimode optical fibres.Nature communications · 2021Article
- Fighting against fast speckle decorrelation for light focusing inside live tissue by photon frequency shifting.ACS photonics · 2020Article
- Focusing light inside live tissue using reversibly switchable bacterial phytochrome as a genetically encoded photochromic guide star.Science advances · 2019Article
- Rapid wide-field imaging through scattering media by digital holographic wavefront correction.Applied optics · 2019Article
- Angular-spectrum modeling of focusing light inside scattering media by optical phase conjugation.Optica · 2019Article
- Implementation of digital optical phase conjugation with embedded calibration and phase rectification.Scientific reports · 2019Article
- Time-reversed magnetically controlled perturbation (TRMCP) optical focusing inside scattering media.Scientific reports · 2018Article
- Time-reversed ultrasonically encoded optical focusing through highly scattering ex vivo human cataractous lenses.Journal of biomedical optics · 2018Article
- Deep tissue optical focusing and optogenetic modulation with time-reversed ultrasonically encoded light.Science advances · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Optical scattering has traditionally limited the ability to focus light inside scattering media such as biological tissue. Recently developed wavefront shaping techniques promise to overcome this limit by tailoring an optical wavefront to constructively interfere at a target location deep inside scattering media. To find such a wavefront solution, a "guide-star" mechanism is required to identify the target location. However, developing guidestars of practical usefulness is challenging, especially in biological tissue, which hinders the translation of wavefront shaping techniques. Here, we demonstrate a guidestar mechanism that relies on magnetic modulation of small particles. This guidestar method features an optical modulation efficiency of 29% and enables micrometer-scale focusing inside biological tissue with a peak intensity-to-background ratio (PBR) of 140; both numbers are one order of magnitude higher than those achieved with the ultrasound guidestar, a popular guidestar method. We also demonstrate that light can be focused on cells labeled with magnetic particles, and to different target locations by magnetically controlling the position of a particle. Since magnetic fields have a large penetration depth even through bone structures like the skull, this optical focusing method holds great promise for deep-tissue applications such as optogenetic modulation of neurons, targeted light-based therapy, and imaging.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.