Evidence map›Paper›PMID 29623046›Full record

ArticleFrontiers in physiology2018

Functional Changes Induced by Orexin A and Adiponectin on the Sympathetic/Parasympathetic Balance.

Antonietta Messina, Marcellino Monda, Anna Valenzano, Giovanni Messina, Ines Villano, Fiorenzo Moscatelli, Giuseppe Cibelli, Gabriella Marsala, Rita Polito, Maria Ruberto and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Exploring the Interplay between Bone Marrow Stem Cells and Obesity.International journal of molecular sciences · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Observational
  11. Physiological Role of Orexinergic System for Health.International journal of environmental research and public health · 2022
    Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Aerobic Exercise and Metabolic Syndrome: The Role of Sympathetic Activity and the Redox System.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020
    Article
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Antonietta MessinaDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli,"Naples, Italy.
Marcellino MondaDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli,"Naples, Italy.
Anna ValenzanoDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Giovanni MessinaDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Ines VillanoDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli,"Naples, Italy.
Fiorenzo MoscatelliDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Giuseppe CibelliDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Gabriella MarsalaStruttura Complessa di Farmacia, Azienda Ospedaliero-Universitaria, Foggia, Italy.
Rita PolitoCEINGE-Biotecnologie Avanzate Scarl, Naples, Italy.
Maria RubertoDepartment of Mental Health, Physical and Preventive Medicine, Clinic of Child and Adolescent Neuropsychiatry, Università degli Studi della Campania "Luigi Vanvitelli,"Naples, Italy.
Marco CarotenutoClinic of Child and Adolescent Neuropsychiatry, Center for Childhood Headache, Department of Mental Health, Physical and Preventive Medicine, University of Campania "Luigi Vanvitelli,"Naples, Italy.
Vincenzo MondaDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli,"Naples, Italy.
Andrea ViggianoDepartment of Medicine and Surgery, University of Salerno, Baronissi, Italy.
Aurora DanieleCEINGE-Biotecnologie Avanzate Scarl, Naples, Italy.
Ersilia NigroCEINGE-Biotecnologie Avanzate Scarl, Naples, Italy.
University of Campania "Luigi Vanvitelli" · ITUniversity of Foggia · ITCeinge Biotecnologie Avanzate (Italy) · ITOspedali Riuniti di Foggia · ITUniversity of Salerno · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity and lifestyle-related diseases are major problems faced by people in developed nations. Although exercise training prevents the progression of diabetes and obesity, the motivation for exercise is generally low in obese animals and humans. The autonomic nervous system (SNA) plays a crucial role in the regulation of eating behavior. Moreover, the SNA is involved in the body temperature regulation that is strictly related to body weight control, in accordance with the "thermoregulatory hypothesis" of food intake. Some neuronal peptides and hormones, like orexins and adiponectin, are also involved in the regulation of locomotion activity as well as food intake and metabolic rate. Furthermore, adiponectin as well as orexin A are involved in the control of body temperature, food intake and therefore in obesity-related diseases. The aim of this study was to investigate the changes in body temperature (Tc), and heart rate (HR) after an intracerebroventricular (ICV) injection of orexin A and adiponectin in animal model. The results of this study show that the orexin A levels are likely involved in the increase of Tc and HR. It is also clear that there is not a correlation between these parameters and adiponectin levels. Further studies are needed to assess adiponectin actions and outcome in the central nervous system in terms of energy expenditure, body temperature, heart rate and physical activity performance regulation.

Indexed as

adiponectinbody temperatureheart rateICV-injectionorexin A

Identifiers

PMID29623046
PMCPMC5874516
OpenAlexW2789835721

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.