Evidence map›Paper›PMID 29622679›Full record

ArticleThe Journal of biological chemistry2018

An intersubunit electrostatic interaction in the GABA

Natasha C Pflanz, Anna W Daszkowski, Garrett L Cornelison, James R Trudell, S John Mihic

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. GABAInternational journal of molecular sciences · 2022
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Natasha C PflanzDepartment of Neuroscience, Division of Pharmacology and Toxicology, Waggoner Center for Alcohol and Addiction Research, Institutes for Neuroscience and Cell and Molecular Biology, University of Texas, Austin, Texas 78712.
Anna W DaszkowskiDepartment of Neuroscience, Division of Pharmacology and Toxicology, Waggoner Center for Alcohol and Addiction Research, Institutes for Neuroscience and Cell and Molecular Biology, University of Texas, Austin, Texas 78712.
Garrett L CornelisonDepartment of Neuroscience, Division of Pharmacology and Toxicology, Waggoner Center for Alcohol and Addiction Research, Institutes for Neuroscience and Cell and Molecular Biology, University of Texas, Austin, Texas 78712.
James R TrudellDepartment of Anesthesia, Stanford University School of Medicine, Stanford, California 94305.
S John MihicDepartment of Neuroscience, Division of Pharmacology and Toxicology, Waggoner Center for Alcohol and Addiction Research, Institutes for Neuroscience and Cell and Molecular Biology, University of Texas, Austin, Texas 78712. Electronic address: mihic@austin.utexas.edu.
The University of Texas at Austin · USStanford University · US

Funding

Molecular Characterization of Benzodiazepine Selectivity: Implications for Drug Discovery and AddictionF31DA042564 · NIDA · UNIVERSITY OF TEXAS AT AUSTIN · PI PFLANZ, NATASHA CHRISTINA · 2016 to 2018
$95k
NIDA NIH HHS F31 DA042564
6 · The paper itself

Abstract

Benzodiazepines are positive allosteric modulators of the GABA

Indexed as

Ion Channel GatingStatic ElectricityAmino Acid SubstitutionAnimalsBenzodiazepinesCrystallography, X-RayGABA ModulatorsHumansProtein ConformationProtein SubunitsReceptors, GABA-AXenopus laevisBenzodiazepinesGABA ModulatorsProtein SubunitsReceptors, GABA-Aallosteric regulationbenzodiazepinesCys-loop receptorcysteine-mediated cross-linkingelectrophysiologyelectrostaticsGABA receptorionotropic receptorsedativeXenopus

Identifiers

PMID29622679
PMCPMC5971448
OpenAlexW2796059853

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.