Evidence map›Paper›PMID 29622660›Full record

ArticleEMBO reports2018

RNase H eliminates R-loops that disrupt DNA replication but is nonessential for efficient DSB repair.

Hongchang Zhao, Min Zhu, Oliver Limbo, Paul Russell

Open access · bronzeAbstract read
In one paragraph

Article in EMBO reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 85 citations in OpenAlex.

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  15. Article
  16. The Fission Yeast Mating-Type Switching Motto: "One-for-Two" and "Two-for-One".Microbiology and molecular biology reviews : MMBR · 2023
    Review
  17. Detecting R-Loop Formation Using a Plasmid-Based In Vitro Transcription Assay.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Hongchang ZhaoDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
Min ZhuDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
Oliver LimboDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0003-1686-1414
Paul RussellDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA prussell@scripps.edu.ORCID 0000-0001-8575-1046
Scripps Research Institute · US

Funding

Studies of the DNA damage checkpointsR01CA077325 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI RUSSELL, PAUL · 1998 to 2017
$7.1M
Studies of the DNA Replication CheckpointR01GM059447 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI RUSSELL, PAUL · 1999 to 2016
$6.0M
Mre11/Rad50 Structural Biology for DNA Damage ResponsesR01CA117638 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI RUSSELL, PAUL, TAINER, JOHN A. · 2005 to 2019
$5.6M
NCI NIH HHS R01 CA077325NCI NIH HHS R01 CA117638NIGMS NIH HHS R01 GM059447
6 · The paper itself

Abstract

In

Indexed as

DNA Breaks, Double-StrandedDNA RepairDNA ReplicationGenomic InstabilityDNA, FungalRibonuclease HRNASaccharomyces cerevisiaeSchizosaccharomycesDNA, FungalRibonuclease HRNAdouble‐strand break repairreplication forkR‐loopRNase H1RNase H2

Identifiers

PMID29622660
PMCPMC5934767
OpenAlexW2795461316

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.