ArticleScience (New York, N.Y.)2018
Enzymatic construction of highly strained carbocycles.
Article in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
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Who cites it
66 citing papers in PubMed.
- Directed evolution of enzymes at the crossroads of tradition and innovation.FEBS open bio · 2026Review
- Chiral medium-sized rings beyond central chirality.Nature reviews. Chemistry · 2025Review
- Emergent Mechanisms in Biocatalysis.ACS central science · 2025Review
- Creating novel metabolic pathways by protein engineering for bioproduction.Trends in biotechnology · 2025Review
- Article
- Pros and Cons in Various Immobilization Techniques and Carriers for Enzymes.Applied biochemistry and biotechnology · 2024Review
- Total Synthesis FacilitatesJournal of the American Chemical Society · 2024Article
- Stereodivergent Synthesis of Pyridyl Cyclopropanes via Enzymatic Activation of Pyridotriazoles.Journal of the American Chemical Society · 2024Article
- Redox Approaches to Carbene Generation in Catalytic Cyclopropanation Reactions.Angewandte Chemie (International ed. in English) · 2024Review
- Rhodium(I)-Catalyzed Annulation of Bicyclo[1.1.0]butyl-Substituted Dihydroquinolines and Dihydropyridines.Journal of the American Chemical Society · 2024Article
- Synthesis of Stereodefined Polysubstituted Bicyclo[1.1.0]butanes.Journal of the American Chemical Society · 2024Article
- Choose Your Own Adventure: A Comprehensive Database of Reactions Catalyzed by Cytochrome P450 BM3 Variants.ACS catalysis · 2024Review
- Enzymatic Assembly of Diverse Lactone Structures: An Intramolecular C-H Functionalization Strategy.Journal of the American Chemical Society · 2024Article
- Bridge Cross-Coupling of Bicyclo[1.1.0]butanes.Organic letters · 2024Article
- The Nature of the Chemical Bonds of High-Valent Transition-Metal Oxo (M=O) and Peroxo (MOO) Compounds: A Historical Perspective of the Metal Oxyl-Radical Character by the Classical to Quantum Computations.Molecules (Basel, Switzerland) · 2023Review
- Recent Synthetic Advances on the Use of Diazo Compounds Catalyzed by Metalloporphyrins.Molecules (Basel, Switzerland) · 2023Review
- Review
- Charting the Evolution of Chemoenzymatic Strategies in the Syntheses of Complex Natural Products.Journal of the American Chemical Society · 2023Review
- Synthesis and Applications of Bicyclo[1.1.0]butyl and Azabicyclo[1.1.0]butyl Organometallics.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Review
- Bicyclobutanes as unusual building blocks for complexity generation in organic synthesis.Communications chemistry · 2023Review
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Small carbocycles are structurally rigid and possess high intrinsic energy due to their ring strain. These features lead to broad applications but also create challenges for their construction. We report the engineering of hemeproteins that catalyze the formation of chiral bicyclobutanes, one of the most strained four-membered systems, via successive carbene addition to unsaturated carbon-carbon bonds. Enzymes that produce cyclopropenes, putative intermediates to the bicyclobutanes, were also identified. These genetically encoded proteins are readily optimized by directed evolution, function in
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.