ArticleJournal of the American Heart Association2018
Genome-Wide Associations of Global Electrical Heterogeneity ECG Phenotype: The ARIC (Atherosclerosis Risk in Communities) Study and CHS (Cardiovascular Health Study).
Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Pooled it
- Shared genetic associations between CHAInternational journal of cardiology. Cardiovascular risk and prevention · 2025Article
- The impact of common and rare genetic variants on bradyarrhythmia development.Nature genetics · 2025Article
- Electrical Heterogeneity in Hispanic Background Subpopulations: The HCHS/SOL.JACC. Advances · 2024Article
- Latent profiles of global electrical heterogeneity: the Hispanic Community Health Study/Study of Latinos.European heart journal. Digital health · 2024Article
- Genetic Susceptibility to Atrial Fibrillation Identified via Deep Learning of 12-Lead Electrocardiograms.Circulation. Genomic and precision medicine · 2023Article
- Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease.Nature communications · 2023Article
- Digitizing ECG image: A new method and open-source software code.Computer methods and programs in biomedicine · 2022Article
- Intermittent fasting and caloric restriction interact with genetics to shape physiological health in mice.Genetics · 2022Article
- Exome sequencing in patient-parent trios suggests new candidate genes for early-onset primary sclerosing cholangitis.Liver international : official journal of the International Association for the Study of the Liver · 2021Article
- A Method to Minimise the Impact of ECG Marker Inaccuracies on the Spatial QRS-T angle: Evaluation on 1,512 Manually Annotated ECGs.Biomedical signal processing and control · 2021Article
- Article
- Global electrical heterogeneity associated with drug-induced torsades de pointes.Heart rhythm · 2021Article
- Kir2.1 Interactome Mapping Uncovers PKP4 as a Modulator of the Kir2.1-Regulated Inward Rectifier Potassium Currents.Molecular & cellular proteomics : MCP · 2020Article
- Going Deep With ECG and Aortic Stenosis: Touchdown or Incomplete Pass?Journal of the American Heart Association · 2020Article
- Changes in global electrical heterogeneity associated with dofetilide, quinidine, ranolazine, and verapamil.Heart rhythm · 2020Article
- Bringing Critical Race Praxis Into the Study of Electrophysiological Substrate of Sudden Cardiac Death: The ARIC Study.Journal of the American Heart Association · 2020Article
- Dynamic predictive accuracy of electrocardiographic biomarkers of sudden cardiac death within a survival framework: the Atherosclerosis Risk in Communities (ARIC) study.BMC cardiovascular disorders · 2019Article
- Vectorcardiogram in athletes: The Sun Valley Ski Study.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2019Article
- Does plastic chemical exposure contribute to sudden death of patients on dialysis?Heart rhythm · 2019Review
Corrections and comments
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Authors and funding
16 authors at 9 institutions in 1 country.
Funding
Abstract
backgroundECG global electrical heterogeneity (GEH) is associated with sudden cardiac death. We hypothesized that a genome-wide association study would identify genetic loci related to GEH. METHODS AND
resultsWe tested genotyped and imputed variants in black (N=3057) and white (N=10 769) participants in the ARIC (Atherosclerosis Risk in Communities) study and CHS (Cardiovascular Health Study). GEH (QRS-T angle, sum absolute QRST integral, spatial ventricular gradient magnitude, elevation, azimuth) was measured on 12-lead ECGs. Linear regression models were constructed with each GEH variable as an outcome, adjusted for age, sex, height, body mass index, study site, and principal components to account for ancestry. GWAS identified 10 loci that showed genome-wide significant association with GEH in whites or joint ancestry. The strongest signal (rs7301677, near
conclusionsWe identified 10 genetic loci associated with ECG GEH. Replication of GEH GWAS findings in independent cohorts is warranted. Further studies of GEH-loci may uncover mechanisms of arrhythmogenic remodeling in response to cardiovascular risk factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.