Evidence map›Paper›PMID 29622581›Full record

ArticleCancer immunology research2018

Targeting Tissue Factor for Immunotherapy of Triple-Negative Breast Cancer Using a Second-Generation ICON.

Zhiwei Hu, Rulong Shen, Amanda Campbell, Elizabeth McMichael, Lianbo Yu, Bhuvaneswari Ramaswamy, Cheryl A London, Tian Xu, William E Carson

Open access · bronzeAbstract read
In one paragraph

Article in Cancer immunology research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 40 citations in OpenAlex.

  1. L-ICON3 Suppresses Endometriosis in a Murine Model.Journal of molecular medicine (Berlin, Germany) · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Advances in PET/CT Imaging for Breast Cancer.Journal of clinical medicine · 2023
    Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Tissue factor: a neglected role in cancer biology.Journal of thrombosis and thrombolysis · 2022
    Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Zhiwei HuDepartment of Surgery Division of Surgical Oncology, The Ohio State University Wexner Medical Center and The OSU James Comprehensive Cancer Center, Columbus, Ohio. zhiwei.hu@osumc.edu.
Rulong ShenDepartment of Pathology, The Ohio State University Wexner Medical Center, Columbus, Ohio.
Amanda CampbellBiomedical Sciences Graduate Program, The Ohio State University, Columbus, Ohio.
Elizabeth McMichaelBiomedical Sciences Graduate Program, The Ohio State University, Columbus, Ohio.
Lianbo YuCenter for Biostatistics, The Ohio State University, Columbus, Ohio.
Bhuvaneswari RamaswamyDepartment of Medical Oncology, The Ohio State University Wexner Medical Center, Columbus, Ohio.
Cheryl A LondonDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio.
Tian XuDepartment of Genetics, Yale University School of Medicine, New Haven, Connecticut.
William E CarsonDepartment of Surgery Division of Surgical Oncology, The Ohio State University Wexner Medical Center and The OSU James Comprehensive Cancer Center, Columbus, Ohio.
The Ohio State University · USThe Ohio State University Wexner Medical Center · USYale University · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
The Ohio State University Center for clinical and Translational ScienceUL1TR001070 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2013 to 2017
$22.6M
Inhibiting Corneal Neovascularization by Targeting Tissue FactorR21EY037451 · NEI · OHIO STATE UNIVERSITY · PI HU, ZHIWEI, ZHU, HUA · 2025 to 2025
$433k
Targeting tissue factor as a novel oncotarget for immunotherapy of triple negative breast cancerR21CA216697 · NCI · OHIO STATE UNIVERSITY · PI HU, ZHIWEI · 2018 to 2019
$368k
Howard Hughes Medical InstituteNCATS NIH HHS UL1 TR001070NCI NIH HHS P30 CA016058NCI NIH HHS R21 CA216697NEI NIH HHS R21 EY037451
6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) is a leading cause of breast cancer death and is often associated with

Indexed as

AnimalsAntineoplastic Agents, ImmunologicalBiomarkers, TumorCell Line, TumorCHO CellsCricetulusDisease Models, AnimalFemaleGene ExpressionHumansImmunoconjugatesImmunohistochemistryMolecular Targeted TherapyMutationThromboplastinTriple Negative Breast NeoplasmsAntineoplastic Agents, ImmunologicalBiomarkers, TumorImmunoconjugatesThromboplastin

Identifiers

PMID29622581
PMCPMC5984705
OpenAlexW2796386675

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.