Evidence map›Paper›PMID 29622578›Full record

Observational studyBMJ open2018

Relationship between islet autoantibody status and the clinical characteristics of children and adults with incident type 1 diabetes in a UK cohort.

Vassiliki Bravis, Akaal Kaur, Helen C Walkey, Ian F Godsland, Shivani Misra, Polly J Bingley, Alistair J K Williams, David B Dunger, Colin M Dayan, Mark Peakman and 3 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 91 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Vassiliki Bravis
Akaal KaurDepartment of Medicine, Imperial College London, London, UK.
Helen C WalkeyDepartment of Medicine, Imperial College London, London, UK.ORCID 0000-0003-3391-0759
Ian F GodslandDepartment of Medicine, Imperial College London, London, UK.
Shivani MisraDepartment of Medicine, Imperial College London, London, UK.
Polly J BingleySchool of Clinical Sciences, University of Bristol, Bristol, UK.
Alistair J K WilliamsSchool of Clinical Sciences, University of Bristol, Bristol, UK.
David B DungerDepartment of Paediatrics, University of Cambridge, Cambridge, UK.
Colin M DayanSchool of Medicine, Cardiff University, Cardiff, UK.
Mark PeakmanDepartment of Immunobiology, King's College London, London, UK.
Nick S OliverDepartment of Medicine, Imperial College London, London, UK.
Desmond G JohnstonDepartment of Medicine, Imperial College London, London, UK.
ADDRESS-2 Management Committee, Patient Advocate Group and Investigators
Imperial College London · GBUniversity of Bristol · GBCardiff University · GBKing's College London · GBUniversity of Cambridge · GB

Funding

Medical Research Council MC_UU_12012/5
6 · The paper itself

Abstract

objectivesTo describe the characteristics of children and adults with incident type 1 diabetes in contemporary, multiethnic UK, focusing on differences between the islet autoantibody negative and positive.

designObservational cohort study.

setting146 mainly secondary care centres across England and Wales.

participants3312 people aged ≥5 years were recruited within 6 months of a clinical diagnosis of type 1 diabetes via the National Institute for Health Research Clinical Research Network. 3021 were of white European ethnicity and 291 (9%) were non-white. There was a small male predominance (57%). Young people <17 years comprised 59%.

main outcome measuresAutoantibody status and characteristics at presentation.

resultsThe majority presented with classical osmotic symptoms, weight loss and fatigue. Ketoacidosis was common (42%), especially in adults, and irrespective of ethnicity. 35% were overweight or obese. Of the 1778 participants who donated a blood sample, 85% were positive for one or more autoantibodies against glutamate decarboxylase, islet antigen-2 and zinc transporter 8. Presenting symptoms were similar in the autoantibody-positive and autoantibody-negative participants, as was the frequency of ketoacidosis (43%vs40%, P=0.3). Autoantibody positivity was less common with increasing age (P=0.0001), in males compared with females (82%vs90%, P<0.0001) and in people of non-white compared with white ethnicity (73%vs86%, P<0.0001). Body mass index was higher in autoantibody-negative adults than autoantibody-positive adults (median, IQR 25.5, 23.1-29.2vs23.9, 21.4-26.7 kg/m

conclusionsMost people assigned a diagnosis of type 1 diabetes presented with classical clinical features and islet autoantibodies. Although indistinguishable at an individual level, autoantibody-negative participants as a group demonstrated features more typically associated with other diabetes subtypes. TRIAL REGISTRATION NUMBER: ISRCTN66496918; Pre-results.

Indexed as

AutoantibodiesDiabetes Mellitus, Type 1AdolescentAdultChildChild, PreschoolCohort StudiesEnglandFemaleHumansIslets of LangerhansMaleWalesAutoantibodiesepidemiologygeneral diabetesimmunologypaediatric endocrinology

Identifiers

PMID29622578
PMCPMC5893930
OpenAlexW2795963770

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.