ArticleBMJ open2018
Interaction of diabetes and smoking on stroke: a population-based cross-sectional survey in China.
Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Article
- Application of bedside HINTS, ABCDStroke and vascular neurology · 2024Article
- Longitudinal trajectories of disability among Chinese adults: the role of cardiometabolic multimorbidity.Aging clinical and experimental research · 2024Article
- Population-based stroke risk profile from a West-African community.eNeurologicalSci · 2023Article
- Changing trends of disease burden of stroke from 1990 to 2019 and its predictions among the Chinese population.Frontiers in neurology · 2023Article
- Interaction Analysis of Abnormal Lipid Indices and Hypertension for Ischemic Stroke: A 10-Year Prospective Cohort Study.Frontiers in cardiovascular medicine · 2022Article
- Diabetes, Vascular Aging and Stroke: Old Dogs, New Tricks?Journal of clinical medicine · 2021Review
- The interaction between detectable plasma viral load and increased body mass index on hypertension among persons living with HIV.AIDS care · 2020Article
- The mediating role of the venules between smoking and ischemic stroke.European journal of epidemiology · 2018Article
- Comprehensive strategies for stroke prevention: A narrative review of population-level risk factor mitigation.Brain circulationReview
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesDiabetes and smoking are known independent risk factors for stroke; however, their interaction concerning stroke is less clear. We aimed to explore such interaction and its influence on stroke in Chinese adults.
designCross-sectional study.
settingCommunity-based investigation in Xuzhou, China.
participantsA total of 39 887 Chinese adults who fulfilled the inclusion criteria were included.
methodsParticipants were selected using a multistage stratified cluster method, and completed self-reported questionnaires on stroke and smoking. Type 2 diabetes mellitus (DM2) was assessed by fasting blood glucose or use of antidiabetic medication. Interaction, relative excess risk owing to interaction (RERI), attributable proportion (AP) and synergy index (S) were evaluated using a logistic regression model.
resultsAfter adjustment for age, sex, marital status, educational level, occupation, physical activity, body mass index, hypertension, family history of stroke, alcohol use and blood lipids, the relationships between DM2 and stroke, and between smoking and stroke, were still significant: ORs were 2.75 (95% CI 2.03 to 3.73) and 1.70 (95% CI 1.38 to 2.10), respectively. In subjects with DM2 who smoked, the RERI, AP and S values (and 95% CIs) were 1.80 (1.24 to 3.83), 0.52 (0.37 to 0.73) and 1.50 (1.18 to 1.84), respectively.
conclusionsThe results suggest there are additive interactions between DM2 and smoking and that these affect stroke in Chinese adults.
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