ArticleEBioMedicine2018
Ebola Virus Persistence in Ocular Tissues and Fluids (EVICT) Study: Reverse Transcription-Polymerase Chain Reaction and Cataract Surgery Outcomes of Ebola Survivors in Sierra Leone.
Article in EBioMedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed, 57 citations in OpenAlex.
- Article
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- Ophthalmological manifestations and plasma markers of inflammation in Ebola survivors in post-treatment era.Scientific reports · 2025Article
- Sudan Virus Persistence in Immune-Privileged Organs of Nonhuman Primate Survivors.Emerging infectious diseases · 2025Article
- Corneal and conjunctival abnormalities in a cohort of survivors from the Western African Ebola virus disease outbreakAJO international · 2024Article
- Ophthalmic Sequelae of Ebola Virus Disease in Survivors, Sierra Leone.Emerging infectious diseases · 2024Article
- Long-term visual outcomes and histopathologic findings after cataract surgery in Ebola virus disease survivors in the Ebola virus RNA persistence in ocular tissues and fluids (EVICT) study.PLoS neglected tropical diseases · 2024Article
- Biosafety and immunology: An interdisciplinary field for health priority.Biosafety and health · 2024Review
- Clinical characteristics and aetiology of uveitis in a viral haemorrhagic fever zone.Eye (London, England) · 2024Article
- Ebola virus disease sequelae and viral persistence in animal models: Implications for the future.PLoS pathogens · 2024Article
- Ebola virus disrupts the inner blood-retinal barrier by induction of vascular endothelial growth factor in pericytes.PLoS pathogens · 2023Article
- Viral Infection and Antiviral Treatments in Ocular Pathologies.Microorganisms · 2022Review
- Persistent intraocular Ebola virus RNA is associated with severe uveitis in a convalescent rhesus monkey.Communications biology · 2022Article
- Ophthalmic sequelae and psychosocial impact in pediatric ebola survivors.EClinicalMedicine · 2022Article
- Ocular manifestations of recent viral pandemics: A literature review.Frontiers in medicine · 2022Review
- Presence of SARS-CoV-2 Viral RNA in Aqueous Humor of Asymptomatic Individuals.American journal of ophthalmology · 2021Article
- Ocular manifestations of emerging viral diseases.Eye (London, England) · 2021Review
- Article
- Characterization of Ebola Virus-Associated Eye Disease.JAMA network open · 2021Article
- Efficacy and Safety Outcomes of Cataract Surgery in Survivors of Ebola Virus Disease: 12-Month Results From the PREVAIL VII Study.Translational vision science & technology · 2021Article
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41 authors at 17 institutions in 6 countries.
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Abstract
backgroundEbola virus disease (EVD) survivors are at risk for uveitis during convalescence. Vision loss has been observed following uveitis due to cataracts. Since Ebola virus (EBOV) may persist in the ocular fluid of EVD survivors for an unknown duration, there are questions about the safety and feasibility of vision restorative cataract surgery in EVD survivors.
methodsWe conducted a cross-sectional study of EVD survivors anticipating cataract surgery and patients with active uveitis to evaluate EBOV RNA persistence in ocular fluid, as well as vision outcomes post cataract surgery. Patients with aqueous humor that tested negative for EBOV RNA were eligible to proceed with manual small incision cataract surgery (MSICS).
findingsWe screened 137 EVD survivors from June 2016 - August 2017 for enrolment. We enrolled 50 EVD survivors; 46 with visually significant cataract, 1 with a subluxated lens, 2 with active uveitis and 1 with a blind painful eye due to uveitis. The median age was 24.0years (IQR 17-35) and 35 patients (70%) were female. The median logMAR visual acuity (VA) was 3.0 (Snellen VA Hand motions; Interquartile Range, IQR: 1.2-3.0, Snellen VA 20/320 - Hand motions). All patients tested negative for EBOV RNA by RT-PCR in aqueous humor/vitreous fluid and conjunctiva at a median of 19months (IQR 18-20) from EVD diagnosis in Phase 1 of ocular fluid sampling and 34months (IQR 32-36) from EVD diagnosis in Phase 2 of ocular fluid sampling. Thirty-four patients underwent MSICS, with a preoperative median VA improvement from hand motions to 20/30 at three-month postoperative follow-up (P<0.001).
interpretationEBOV persistence by RT-PCR was not identified in ocular fluid or conjunctivae of fifty EVD survivors with ocular disease. Cataract surgery can be performed safely with vision restorative outcomes in patients who test negative for EBOV RNA in ocular fluid specimens. These findings impact the thousands of West African EVD survivors at-risk for ocular complications who may also require eye surgery during EVD convalescence.
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