Evidence map›Paper›PMID 29622466›Full record

ArticleCancer cell2018

Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas.

Yang Liu, Nilay S Sethi, Toshinori Hinoue, Barbara G Schneider, Andrew D Cherniack, Francisco Sanchez-Vega, Jose A Seoane, Farshad Farshidfar, Reanne Bowlby, Mirazul Islam and 18 more

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 352 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
352citing papers in PubMed, 1 pooled it
56.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

352 citing papers in PubMed, 1 synthesis or guideline pooled it, 706 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Dysregulated immune microenvironment in metastatic colorectal cancer.Medical oncology (Northwood, London, England) · 2026
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

292 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 17 institutions in 3 countries.

Yang LiuThe Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Nilay S SethiThe Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Toshinori HinoueCenter for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA.
Barbara G SchneiderDepartment of Medicine, Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Andrew D CherniackThe Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Francisco Sanchez-VegaComputational Biology Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Jose A SeoaneDepartment of Medicine, and Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Farshad FarshidfarDepartment of Oncology, Cumming School of Medicine, University of Calgary, Calgarry, Canada.
Reanne BowlbyCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada.
Mirazul IslamThe Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Jaegil KimThe Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Walid ChatilaDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Rehan AkbaniDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Rupa S KanchiDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Charles S RabkinDivision of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
Joseph E WillisDepartment of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
Kenneth K WangDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA.
Shannon J McCallDepartment of Pathology, Duke University, Durham, NC 27710, USA.
Lopa MishraCenter for Translational Research, Department of Surgery, George Washington University Cancer Center, Washington, DC 20052, USA.
Akinyemi I OjesinaDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA; HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Susan BullmanDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Chandra Sekhar PedamalluDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Alexander J LazarDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Ryo SakaiPharmiWeb Solutions, Bracknell RG12 1QB, UK.
Cancer Genome Atlas Research Network
Vésteinn ThorssonInstitute for Systems Biology, Seattle, WA 98109, USA. Electronic address: vesteinn.thorsson@systemsbiology.org.
Adam J BassThe Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address: adam_bass@dfci.harvard.edu.
Peter W LairdCenter for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA. Electronic address: peter.laird@vai.org.
Broad Institute · USDana-Farber Cancer Institute · USVan Andel Institute · USThe University of Texas MD Anderson Cancer Center · USMayo Clinic in Arizona · USCase Western Reserve University · USMemorial Sloan Kettering Cancer Center · USBC Cancer Agency · CABristol-Myers Squibb (Belgium) · BEInstitute for Systems Biology · USDuke University · USUniversity of Alabama at Birmingham · USNational Cancer Institute · USUniversity of Calgary · CAGeorge Washington University · USStanford University · USVanderbilt University Medical Center · US

Funding

Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6M
Large Scale Genome SequencingU54HG003079 · NHGRI · WASHINGTON UNIVERSITY · PI DUTCHER, SUSAN K · 2004 to 2016
$445.7M
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
The Human Genome Sequencing CenterU54HG003273 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A · 2004 to 2015
$341.3M
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Transformed Esophageal Epithelial Cells and the Tumor MicroenvironmentP01CA098101 · NCI · UNIVERSITY OF PENNSYLVANIA · PI RUSTGI, ANIL K · 2003 to 2023
$31.7M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Gene Expression Patterns in Human Tumors Identified Using Transcript SequencingU24CA143848 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HAYES, DAVID N, PEROU, CHARLES M · 2009 to 2016
$20.8M
Physician Scientist Training in Cancer ResearchT32CA009172 · NCI · DANA-FARBER CANCER INSTITUTE · PI Jennifer R Brown, James A. DeCaprio · 1985 to 2026
$17.1M
Genome Characterization Center (GCC)U24CA143867 · NCI · BROAD INSTITUTE, INC. · PI GABRIEL, STACEY, MEYERSON, MATTHEW L. · 2009 to 2016
$17.0M
The Cancer Genome Atlas Data Analysis CenterU24CA143845 · NCI · BROAD INSTITUTE, INC. · PI CHIN, LYNDA, GETZ, GAD A · 2009 to 2016
$16.0M
Harvard Genome Characterization CenterU24CA144025 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI KUCHERLAPATI, RAJU S. · 2009 to 2016
$14.0M
BLRD VA I01 BX003732NCI NIH HHS P01 CA098101NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA163722NCI NIH HHS R01 CA236591NCI NIH HHS R50 CA221675NCI NIH HHS T32 CA009172NCI NIH HHS U24 CA143799NCI NIH HHS U24 CA143835NCI NIH HHS U24 CA143840NCI NIH HHS U24 CA143843NCI NIH HHS U24 CA143845NCI NIH HHS U24 CA143848NCI NIH HHS U24 CA143858NCI NIH HHS U24 CA143866NCI NIH HHS U24 CA143867NCI NIH HHS U24 CA143882NCI NIH HHS U24 CA143883NCI NIH HHS U24 CA144025NCI NIH HHS U24 CA199461NCI NIH HHS U24 CA210949NCI NIH HHS U24 CA210950NCI NIH HHS U24 CA210957NCI NIH HHS U24 CA210969NCI NIH HHS U24 CA210990NCI NIH HHS U24 CA210999NHGRI NIH HHS U54 HG003067NHGRI NIH HHS U54 HG003079NHGRI NIH HHS U54 HG003273NIAAA NIH HHS R01 AA023146NIDDK NIH HHS P30 DK058404
6 · The paper itself

Abstract

We analyzed 921 adenocarcinomas of the esophagus, stomach, colon, and rectum to examine shared and distinguishing molecular characteristics of gastrointestinal tract adenocarcinomas (GIACs). Hypermutated tumors were distinct regardless of cancer type and comprised those enriched for insertions/deletions, representing microsatellite instability cases with epigenetic silencing of MLH1 in the context of CpG island methylator phenotype, plus tumors with elevated single-nucleotide variants associated with mutations in POLE. Tumors with chromosomal instability were diverse, with gastroesophageal adenocarcinomas harboring fragmented genomes associated with genomic doubling and distinct mutational signatures. We identified a group of tumors in the colon and rectum lacking hypermutation and aneuploidy termed genome stable and enriched in DNA hypermethylation and mutations in KRAS, SOX9, and PCBP1.

Indexed as

Chromosomal InstabilityDNA MethylationAdenocarcinomaAneuploidyDNA-Binding ProteinsDNA Polymerase IIEpigenesis, GeneticFemaleGastrointestinal NeoplasmsGene Regulatory NetworksHeterogeneous-Nuclear RibonucleoproteinsHumansMaleMicrosatellite InstabilityMutationMutL Protein Homolog 1DNA-Binding ProteinsDNA Polymerase IIHeterogeneous-Nuclear RibonucleoproteinsKRAS protein, humanMLH1 protein, humanMutL Protein Homolog 1PCBP1 protein, humanPOLE protein, humanPoly-ADP-Ribose Binding ProteinsProto-Oncogene Proteins p21(ras)RNA-Binding ProteinsSOX9 protein, humanSOX9 Transcription Factorcancercoloncolorectalepigeneticesophagusgenomicmethylationrectumstomachtumor

Identifiers

PMID29622466
PMCPMC5966039
OpenAlexW2795622837

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.