ArticleCancer imaging : the official publication of the International Cancer Imaging Society2018
Ultrasound shear wave elastography of breast lesions: correlation of anisotropy with clinical and histopathological findings.
Article in Cancer imaging : the official publication of the International Cancer Imaging Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- APRIL: Adaptive Regression-Based Two-Dimensional Quantitative Anisotropy Imaging Using Acoustic Radiation Force Impulse.bioRxiv : the preprint server for biology · 2026Article
- Predictive value of elastography (Shear-Wave and Elasticity Index) in differentiating benign from malignant breast lesions: a retrospective study in Peru.Radiology and oncology · 2026Observational
- Surface Compression Alters in Vivo VisR Stiffness, Viscosity, and Anisotropy Measurements in Human Breast.IEEE open journal of ultrasonics, ferroelectrics, and frequency control · 2025Article
- Correlation between SWE parameters and histopathological features and immunohistochemical biomarkers in invasive breast cancer.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Article
- Full-field noise-correlation elastography for in-plane mechanical anisotropy imaging.Biomedical optics express · 2024Article
- Emerging Role of Quantitative Ultrasound-Based Imaging Techniques for Characterizing Rotator Cuff Tears: A Scoping Review.Diagnostics (Basel, Switzerland) · 2023Article
- Quantitative Assessment of Breast-Tumor Stiffness Using Shear-Wave Elastography Histograms.Diagnostics (Basel, Switzerland) · 2022Article
- Quantitative Estimation of Mechanical Anisotropy Using Acoustic Radiation Force (ARF)-Induced Peak Displacements (PD): In Silico and Experimental Demonstration.IEEE transactions on medical imaging · 2022Article
- Can shear wave elastography be utilized as an additional tool for the assessment of non-mass breast lesions?Ultrasound (Leeds, England) · 2022Article
- Ex Vivo Evaluation of Mechanical Anisotropic Tissues with High-Frequency Ultrasound Shear Wave Elastography.Sensors (Basel, Switzerland) · 2022Article
- Relationship of shear wave elastography anisotropy with tumor stem cells and epithelial-mesenchymal transition in breast cancer.BMC medical imaging · 2021Article
- Prediction of Invasive Breast Cancer Using Mass Characteristic Frequency and Elasticity in Correlation with Prognostic Histologic Features and Immunohistochemical Biomarkers.Ultrasound in medicine & biology · 2021Article
- Electronic Point Spread Function Rotation Using a Three-Row Transducer for ARFI-Based Elastic Anisotropy Assessment: In Silico and Experimental Demonstration.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Individualized-thresholding Shear Wave Elastography combined with clinical factors improves specificity in discriminating breast masses.Breast (Edinburgh, Scotland) · 2020Article
- Article
- Feasibility between Bifidobacteria Targeting and Changes in the Acoustic Environment of tumor Tissue for Synergistic HIFU.Scientific reports · 2020Article
- A multicenter study of a contrast-enhanced ultrasound diagnostic classification of breast lesions.Cancer management and research · 2019Article
- Time Steps Expandable Inverse Model for Ultrasound Shear Wave Elastography Imaging.Journal of medical physicsArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundUltrasound shear-wave elastography (SWE) may increase specificity of breast lesion assessment with ultrasound, but elasticity measurements may change with transducer orientation, defined as anisotropy. In this study, we aimed to observe the anisotropy of SWE of breast lesions, and its correlation with clinical and histopathological findings.
methodsThis retrospective study was approved by institutional review board. From June 2014 to June 2015, a total of 276 women (mean age, 48.75 ± 12.12 years) with 276 breast lesions (174 malignant, 102 benign) were enrolled for conventional ultrasound and SWE before surgical excision. Elasticity modulus in the longest diameter and orthogonal diameter were recorded, including maximum elasticity (Emax), mean elasticity (Emean), standard deviation (Esd) and ratio between mean elasticity of lesion and normal fatty tissue (Eratio). Anisotropy coefficients including anisotropic difference (AD) and anisotropy factors (AF) were calculated, and correlations with malignancy, tumor size, palpability, movability, lesion location and histopathology were analyzed.
resultsThe average Emax, Emean, Esd and Eratio of the longest diameter were significantly higher than orthogonal diameter (P < 0.05). AUCs of ADs and AFs were inferior to quantitative parameters (P < 0.001), with AUCs of AFs superior to ADs (P < 0.001). ADs showed no significant correlation with malignancy, palpability, movability, distance from nipple and skin, and histopathological patterns. ADmean was significantly higher in inner half than outer half of the breast (P = 0.034). Higher AFs were significantly correlated with larger lesion size (P = 0.042), palpability (P < 0.05), shorter distance from nipple and skin (P < 0.05) and higher suspicion for malignancy (P < 0.001). AFs were significantly higher in IDC than DCIS (P < 0.05), higher in Grade II/III than Grade I IDC (P < 0.001), and correlated with ER/PR(+) (P < 0.05).
conclusionsAF of SWE was an indicator for malignancy and more aggressive breast cancer.
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