ArticleJournal of orthopaedic surgery and research2018
Detection of calcium pyrophosphate dihydrate crystals in knee meniscus by dual-energy computed tomography.
Article in Journal of orthopaedic surgery and research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Chondrocalcinosis does not affect functional outcome and prosthesis survival in patients after total or unicompartmental knee arthroplasty: a systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022Pooled it
- Review
- Review
- Imaging and management of calcium pyrophosphate deposition disease.Skeletal radiology · 2025Review
- Advanced imaging techniques in crystal arthritis.Therapeutic advances in musculoskeletal disease · 2025Review
- Dual-energy CT in musculoskeletal imaging: technical considerations and clinical applications.La Radiologia medica · 2024Review
- Dual energy computed tomography cannot effectively differentiate between calcium pyrophosphate and basic calcium phosphate diseases in the clinical setting.Osteoarthritis and cartilage open · 2024Article
- Imaging Features of Calcium Pyrophosphate Deposition Disease: Consensus Definitions From an International Multidisciplinary Working Group.Arthritis care & research · 2023Article
- Identifying Potential Classification Criteria for Calcium Pyrophosphate Deposition Disease: Item Generation and Item Reduction.Arthritis care & research · 2022Review
- Periarticular calcifications.Skeletal radiology · 2022Review
- The role of dual energy computed tomography in the differentiation of acute gout flares and acute calcium pyrophosphate crystal arthritis.Clinical rheumatology · 2022Article
- Review: Outcome measures in calcium pyrophosphate deposition.Best practice & research. Clinical rheumatology · 2021Review
- A critical review of the available evidence on the diagnosis and clinical features of CPPD: do we really need imaging?Clinical rheumatology · 2021Review
- The role of Interleukin-1 receptor antagonist as a treatment option in calcium pyrophosphate crystal deposition disease.Molecular biology reports · 2021Review
- Calcium pyrophosphate crystal size and characteristics.Osteoarthritis and cartilage open · 2021Article
- Review
- Calcium pyrophosphate deposition disease: The role of imaging in their detection and in differential diagnosis of crystal arthropathies.Radiology case reports · 2020Article
- Utility of Ultrasound and Dual Energy CT in Crystal Disease Diagnosis and Management.Current rheumatology reports · 2020Review
- A prospective study of dual-energy CT scanning, US and X-ray in acute calcium pyrophosphate crystal arthritis.Rheumatology (Oxford, England) · 2020Article
- Issues in CPPD Nomenclature and Classification.Current rheumatology reports · 2019Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCalcium pyrophosphate dihydrate (CPPD) crystals are commonly observed in osteoarthritic joints. The aim of our study was to investigate the efficacy of a dual-energy computed tomography (DECT) for detecting CPPD crystals in knee meniscus.
methodsTwenty-six patients undergoing primary total knee arthroplasty were included in the study. Radiographs of knee joint and synovial fluid specimens were analyzed for the presence of CPPD crystals. Meniscus extracted during surgery was scanned using DECT. Sensitivity and specificity of DECT and radiograph for detecting CPPD crystals were calculated against a reference standard (polarizing light microscopy of synovial fluid aspirate). Meniscus in which CPPD crystals were suspected with DECT was further examined to confirm the crystals using a polarized microscopy.
resultsCPPD crystals in synovial fluid were observed in 9 (36%) patients. The sensitivity and specificity of DECT in the detection of CPPD crystals, against microscopic identification, were 77.8 and 93.8%, respectively. The sensitivity and specificity of conventional radiography in the detection of CPPD crystals were 44.4 and 100%, respectively. DECT was able to detect the area where CPPD crystals were deposited in the meniscus.
conclusionDECT provides good diagnostic sensitivity and specificity for detection of CPPD crystals in knee meniscus as well as spatial information about CPPD crystals. DECT is currently a research tool, but we believe that DECT can be a useful instrument to diagnose CPPD deposition disease, especially for the regions where aspiration is difficult to be performed such as pubic symphysis, atlantoaxial joint, interphalangeal joint.
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