ArticleJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc2018
Intestinal lesions in dogs with acute hemorrhagic diarrhea syndrome associated with netF-positive Clostridium perfringens type A.
Article in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Identification and structural characterization of anthrax toxin receptor 2 as the Clostridium perfringens NetF receptor.Nature communications · 2026Article
- Prevalence and toxin gene profiles ofJournal of veterinary science · 2025Article
- Clinical Guidelines for Fecal Microbiota Transplantation in Companion Animals.Advances in small animal care · 2024Article
- Genome sequences ofMicrobiology resource announcements · 2024Article
- The Effect of Metronidazole versus a Synbiotic on Clinical Course and Core Intestinal Microbiota in Dogs with Acute Diarrhea.Veterinary sciences · 2024Article
- Evaluation of Intestinal Barrier Dysfunction with Serum Iohexol Concentration in Dogs with Acute Hemorrhagic Diarrhea Syndrome.Animals : an open access journal from MDPI · 2024Article
- Defining a metagenomic threshold for detecting low abundances ofFrontiers in cellular and infection microbiology · 2024Article
- Fecal Protein Profile in Eight Dogs Suffering from Acute Uncomplicated Diarrhea before and after Treatment.Veterinary sciences · 2023Article
- Clinical response in dogs with acute hemorrhagic diarrhea syndrome following randomized probiotic treatment or fecal microbiota transplant.Frontiers in veterinary science · 2023Article
- The Mechanism of Important Components in Canine Fecal Microbiota Transplantation.Veterinary sciences · 2022Review
- Frequency of signs of chronic gastrointestinal disease in dogs after an episode of acute hemorrhagic diarrhea.Journal of veterinary internal medicine · 2022Article
- C-reactive protein as a tool for monitoring response to treatment in dogs with acute hemorrhagic diarrhea syndrome.Frontiers in veterinary science · 2022Review
- An Official Outbreak Investigation of Acute Haemorrhagic Diarrhoea in Dogs in Norway Points toAnimals : an open access journal from MDPI · 2021Article
- Changes in the fecal microbiota in dogs with acute hemorrhagic diarrhea during an outbreak in Norway.Journal of veterinary internal medicine · 2021Article
- Faecal Microbiome Transplantation as a Solution to Chronic Enteropathies in Dogs: A Case Study of Beneficial Microbial Evolution.Animals : an open access journal from MDPI · 2021Article
- Article
- Catching a glimpse of the bacterial gut community of companion animals: a canine and feline perspective.Microbial biotechnology · 2020Review
- Effects of metronidazole on the fecal microbiome and metabolome in healthy dogs.Journal of veterinary internal medicine · 2020Article
- Fatal Clostridium sordellii-mediated hemorrhagic and necrotizing gastroenteropathy in a dog: case report.BMC veterinary research · 2020Article
- Effect of amoxicillin-clavulanic acid on clinical scores, intestinal microbiome, and amoxicillin-resistant Escherichia coli in dogs with uncomplicated acute diarrhea.Journal of veterinary internal medicine · 2020Article
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute hemorrhagic diarrhea syndrome (AHDS), formerly named canine hemorrhagic gastroenteritis, is one of the most common causes of acute hemorrhagic diarrhea in dogs, and is characterized by acute onset of diarrhea, vomiting, and hemoconcentration. To date, histologic examinations have been limited to postmortem specimens of only a few dogs with AHDS. Thus, the aim of our study was to describe in detail the distribution, character, and grade of microscopic lesions, and to investigate the etiology of AHDS. Our study comprised 10 dogs with AHDS and 9 control dogs of various breeds, age, and sex. Endoscopic biopsies of the gastrointestinal tract were taken and examined histologically (H&E, Giemsa), immunohistochemically ( Clostridium spp., parvovirus), and bacteriologically. The main findings were acute necrotizing and neutrophilic enterocolitis (9 of 10) with histologic detection of clostridia-like, gram-positive bacteria on the necrotic mucosal surface (9 of 10). Clostridium perfringens isolated from the duodenum was identified as type A (5 of 5) by multiplex PCR (5 of 5). In addition, each of the 5 genotyped isolates encoded the pore-forming toxin netF. Clostridium spp. (not C. perfringens) were cultured from duodenal biopsies in 2 of 9 control dogs. These findings suggest that the pore-forming netF toxin is responsible for the necrotizing lesions in the intestines of a significant proportion of dogs with AHDS. Given that the stomach was not involved in the process, the term "acute hemorrhagic diarrhea syndrome" seems more appropriate than the frequently used term "hemorrhagic gastroenteritis."
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