Evidence map›Paper›PMID 29621487›Full record

ArticleNeuron2018

A Hypothalamic Midbrain Pathway Essential for Driving Maternal Behaviors.

Yi-Ya Fang, Takashi Yamaguchi, Soomin C Song, Nicolas X Tritsch, Dayu Lin

Abstract read
In one paragraph

Article in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers.

0numbers the graph read from it
0cells of the map it votes in
142citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

142 citing papers in PubMed.

  1. Neural circuits for mammalian parental behaviour.Nature reviews. Neuroscience · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Paternal behavior is controlled by preoptic Trpc5 neurons.bioRxiv : the preprint server for biology · 2026
    Article
  13. The neural control of infanticide and parental behaviors in male mice.bioRxiv : the preprint server for biology · 2026
    Article
  14. Review
  15. Article
  16. Article
  17. Neural plasticity supporting parental behaviors.Current opinion in neurobiology · 2025
    Review
  18. Context rescales a social action code in a hormone-sensitive network.bioRxiv : the preprint server for biology · 2025
    Article
  19. Review
  20. Review

82 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Yi-Ya FangNeuroscience Institute, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA.
Takashi YamaguchiNeuroscience Institute, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA.
Soomin C SongNeuroscience Institute, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA.
Nicolas X TritschNeuroscience Institute, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA.
Dayu LinNeuroscience Institute, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA; Department of Psychiatry, New York University School of Medicine, 1 Park Avenue, New York, NY 10016, USA; Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA. Electronic address: dayu.lin@nyumc.org.

Funding

Research Supplement to Promote Diversity in Health-Related ResearchR01MH101377 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Dayu Lin · 2013 to 2026
$8.6M
A novel framework for the functional dissection of motor systemsDP2NS105553 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TRITSCH, NICOLAS XAVIER · 2017 to 2017
$2.5M
Dopaminergic modulation of brain circuits that control movementR00NS087098 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TRITSCH, NICOLAS XAVIER · 2016 to 2018
$747k
Investigating the neural mechanism of maternal motivationR21HD090563 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LIN, DAYU · 2018 to 2019
$466k
Understand the neural mechanism underlying aggressive motivationR21MH105774 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LIN, DAYU · 2016 to 2017
$466k
NICHD NIH HHS R21 HD090563NIMH NIH HHS R01 MH101377NIMH NIH HHS R21 MH105774NINDS NIH HHS DP2 NS105553NINDS NIH HHS R00 NS087098
6 · The paper itself

Abstract

Maternal behaviors are essential for the survival of the young. Previous studies implicated the medial preoptic area (MPOA) as an important region for maternal behaviors, but details of the maternal circuit remain incompletely understood. Here we identify estrogen receptor alpha (Esr1)-expressing cells in the MPOA as key mediators of pup approach and retrieval. Reversible inactivation of MPOA

Indexed as

AnimalsEstrogen Receptor alphaFemaleHypothalamusMaternal BehaviorMesencephalonMiceMice, Inbred C57BLMice, TransgenicNeural PathwaysOrgan Culture TechniquesPreoptic AreaVentral Tegmental AreaEstrogen Receptor alphadopamineelectrophysiologyestrogen receptor alphahypothalamusmaternal behaviorsmedial preoptic areaneural circuitoptogeneticspup retrievalventral tegmental area

Identifiers

PMID29621487
PMCPMC5890946

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.