Evidence map›Paper›PMID 29621484›Full record

ArticleNeuron2018

Rbfox1 Regulates Synaptic Transmission through the Inhibitory Neuron-Specific vSNARE Vamp1.

Celine K Vuong, Weizheng Wei, Ji-Ann Lee, Chia-Ho Lin, Andrey Damianov, Luis de la Torre-Ubieta, Reem Halabi, Klara Olofsdotter Otis, Kelsey C Martin, Thomas J O'Dell and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 106 citations in OpenAlex.

  1. Genetic and epigenetic signatures associated with plasma oxytocin levels in children and adolescents with autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2023
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  9. Comprehensive characterization of the RNA editing landscape in the human aging brains with Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Celine K VuongMolecular Biology Interdepartmental Doctoral Program, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Weizheng WeiDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Ji-Ann LeeDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Chia-Ho LinDepartment of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Andrey DamianovDepartment of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Luis de la Torre-UbietaDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Reem HalabiDepartment of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Klara Olofsdotter OtisDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Kelsey C MartinDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Thomas J O'DellDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Douglas L BlackDepartment of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: dougb@microbio.ucla.edu.
University of California, Los Angeles · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
UCLA NIGMS T32 Program AssessmentT32GM007185 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TORRES, JORGE · 1985 to 2020
$21.7M
RELIABILITY DETECTION MECHANISMS IN LTP INDUCTIONR01MH060919 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI O'DELL, THOMAS J · 2000 to 2016
$4.4M
Mechanisms of Alternative Splicing Regulation by Rbfox ProteinsR01GM114463 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BLACK, DOUGLAS L · 2016 to 2019
$1.7M
Cytoplasmic Functions of Rbfox1, a Candidate Autism GeneR21MH101684 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARTIN, KELSEY C · 2013 to 2014
$424k
Control of inhibitory synaptic transmission by the splicing regulator Rbfox1F31NS093923 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VUONG, CELINE K. · 2015 to 2016
$73k
NCI NIH HHS P30 CA016042NIGMS NIH HHS R01 GM114463NIGMS NIH HHS T32 GM007185NIMH NIH HHS R01 MH060919NIMH NIH HHS R21 MH101684NINDS NIH HHS F31 NS093923
6 · The paper itself

Abstract

Dysfunction of the neuronal RNA binding protein RBFOX1 has been linked to epilepsy and autism spectrum disorders. Rbfox1 loss in mice leads to neuronal hyper-excitability and seizures, but the physiological basis for this is unknown. We identify the vSNARE protein Vamp1 as a major Rbfox1 target. Vamp1 is strongly downregulated in Rbfox1 Nes-cKO mice due to loss of 3' UTR binding by RBFOX1. Cytoplasmic Rbfox1 stimulates Vamp1 expression in part by blocking microRNA-9. We find that Vamp1 is specifically expressed in inhibitory neurons, and that both Vamp1 knockdown and Rbfox1 loss lead to decreased inhibitory synaptic transmission and E/I imbalance. Re-expression of Vamp1 selectively within interneurons rescues the electrophysiological changes in the Rbfox1 cKO, indicating that Vamp1 loss is a major contributor to the Rbfox1 Nes-cKO phenotype. The regulation of interneuron-specific Vamp1 by Rbfox1 provides a paradigm for broadly expressed RNA-binding proteins performing specialized functions in defined neuronal subtypes.

Indexed as

AnimalsCells, CulturedFemaleMaleMiceMice, 129 StrainMice, Inbred C57BLMice, KnockoutMice, TransgenicNeural InhibitionNeuronsRNA Splicing FactorsSNARE ProteinsSynaptic TransmissionVesicle-Associated Membrane Protein 1Rbfox1 protein, mouseRNA Splicing FactorsSNARE ProteinsVesicle-Associated Membrane Protein 1vesicle-associated membrane protein 1, mouseE/I balanceinhibitory synaptic transmissionmicroRNA-9posttranscriptional regulationRbfox1RNA-binding proteinVamp1

Identifiers

PMID29621484
PMCPMC5890944
OpenAlexW2796191989

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.