Evidence map›Paper›PMID 29621480›Full record

SynthesisAlzheimer's & dementia : the journal of the Alzheimer's Association2018

Identifying dementia cases with routinely collected health data: A systematic review.

Tim Wilkinson, Amanda Ly, Christian Schnier, Kristiina Rannikmäe, Kathryn Bush, Carol Brayne, Terence J Quinn, Cathie L M Sudlow, UK Biobank Neurodegenerative Outcomes Group and Dementias Platform UK

Registry-linked trialAbstract readSystematic Review
In one paragraph

Synthesis in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04912245 (A Telehealth Advance Care Planning Intervention in Those With Mild Cognitive Impairment or Unrecognized Dementia), which is not on this map. Cited by 165 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
165citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04912245 nacompletednot on this mapstarted 2021, after this paper: background citation

A Telehealth Advance Care Planning Intervention in Those With Mild Cognitive Impairment or Unrecognized Dementia (Tele Voice)

TypeinterventionalSponsorWake Forest University Health SciencesRan2021 to 2022Enrolled152ConditionsAdvance Care Planning, Telemedicine, Mild Cognitive Impairment, Unrecognized DementiaArmsTelehealth visit
3 · Its place in the literature

Who cites it

165 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  7. Observational
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  11. Angiotensin receptor blockers and dementia risk in older adults: A target trial emulation.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  18. Traumatic brain injury and risk of early-onset dementia: A population-based cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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105 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tim WilkinsonCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, Scotland; Usher Institute of Population Health Sciences and Informatics, Nine Bioquarter, Edinburgh, Scotland. Electronic address: tim.wilkinson@ed.ac.uk.
Amanda LyUsher Institute of Population Health Sciences and Informatics, Nine Bioquarter, Edinburgh, Scotland.
Christian SchnierUsher Institute of Population Health Sciences and Informatics, Nine Bioquarter, Edinburgh, Scotland.
Kristiina RannikmäeCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, Scotland; Usher Institute of Population Health Sciences and Informatics, Nine Bioquarter, Edinburgh, Scotland.
Kathryn BushCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, Scotland; Usher Institute of Population Health Sciences and Informatics, Nine Bioquarter, Edinburgh, Scotland.
Carol BrayneInstitute of Public Health, Cambridge University, Cambridge, UK.
Terence J QuinnInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland.
Cathie L M SudlowCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, Scotland; Usher Institute of Population Health Sciences and Informatics, Nine Bioquarter, Edinburgh, Scotland; UK Biobank, Coordinating Centre, Stockport, UK.
UK Biobank Neurodegenerative Outcomes Group and Dementias Platform UK

Funding

Medical Research Council MR/P001823/1
6 · The paper itself

Abstract

introductionProspective, population-based studies can be rich resources for dementia research. Follow-up in many such studies is through linkage to routinely collected, coded health-care data sets. We evaluated the accuracy of these data sets for dementia case identification.

methodsWe systematically reviewed the literature for studies comparing dementia coding in routinely collected data sets to any expert-led reference standard. We recorded study characteristics and two accuracy measures-positive predictive value (PPV) and sensitivity.

resultsWe identified 27 eligible studies with 25 estimating PPV and eight estimating sensitivity. Study settings and methods varied widely. For all-cause dementia, PPVs ranged from 33%-100%, but 16/27 were >75%. Sensitivities ranged from 21% to 86%. PPVs for Alzheimer's disease (range 57%-100%) were generally higher than those for vascular dementia (range 19%-91%). DISCUSSION: Linkage to routine health-care data can achieve a high PPV and reasonable sensitivity in certain settings. Given the heterogeneity in accuracy estimates, cohorts should ideally conduct their own setting-specific validation.

Indexed as

Delivery of Health CareAlzheimer DiseaseClinical CodingData CollectionDementia, VascularHumansSensitivity and SpecificityAlzheimer's diseaseClinical codingCohort studiesDementiaEpidemiologyPositive predictive valuePredictive value of testsProspective studiesSensitivityVascular

Identifiers

PMID29621480
PMCPMC6105076

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.