ArticlePloS one2018
Sexual dimorphism in the association between gestational diabetes mellitus and overweight in offspring at 5-7 years: The OBEGEST cohort study.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Influence of maternal obesity on the association between common pregnancy complications and risk of childhood obesity: an individual participant data meta-analysis.The Lancet. Child & adolescent health · 2018Pooled it
- Maternal dysglycaemia, changes in the infant's epigenome modified with a diet and physical activity intervention in pregnancy: Secondary analysis of a randomised control trial.PLoS medicine · 2020Trial
- Sex-specific signatures of fetal programming for gestational diabetes mellitus in umbilical cord: A cohort study from Tanzania.BMC medicine · 2026Observational
- Gestational Diabetes Mellitus, Glycemic Management Trajectories, and Offspring Growth Patterns and Obesity Risk.Diabetes care · 2026Article
- Advances in Research on Childhood-Obesity Associated With Gestational Diabetes Mellitus.Journal of diabetes · 2026Review
- Fetal sex-specific differences in the placental transcriptome of gestational diabetes.Scientific reports · 2026Observational
- In-utero exposure to maternal diabetes and DNA methylation alterations in the Next Generation birth cohort.Clinical epigenetics · 2025Article
- The Adverse Influence of Maternal Glycaemia During Pregnancy on Offspring's Cardiometabolic Health Profiles.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Mechanisms of Fetal Overgrowth in Gestational Diabetes: The Potential Role of SOCS2.Nutrients · 2025Review
- Women's Health Across the Lifespan: A Sex- and Gender-Focused Perspective.Physical therapy · 2024Review
- Effect of high-fat diet on the fatty acid profiles of brain in offspring mice exposed to maternal gestational diabetes mellitus.International journal of obesity (2005) · 2024Article
- Alternative splicing events as peripheral biomarkers for motor learning deficit caused by adverse prenatal environments.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Sex differences in glycolipidic disorders after exposure to maternal hyperglycemia during early development.Journal of endocrinological investigation · 2023Review
- Metformin Impacts Human Syncytiotrophoblast Mitochondrial Function from Pregnancies Complicated by Obesity and Gestational Diabetes Mellitus in a Sexually Dimorphic Manner.Antioxidants (Basel, Switzerland) · 2023Article
- Analysis of Pregnancy Complications and Epigenetic Gestational Age of Newborns.JAMA network open · 2023Article
- Cannabidiol treatment improves metabolic profile and decreases hypothalamic inflammation caused by maternal obesity.Frontiers in nutrition · 2023Article
- Associations Between Maternal Lipid Blood Levels at the 13th Week of Pregnancy and Offspring's Adiposity at Age 11-12 Years.The Journal of clinical endocrinology and metabolism · 2022Article
- Sex differences in preterm nutrition and growth: the evidence from human milk associated studies.Journal of perinatology : official journal of the California Perinatal Association · 2022Review
- Preterm birth and metabolic implications on later life: A narrative review focused on body composition.Frontiers in nutrition · 2022Review
- Looking at the Future Through the Mother's Womb: Gestational Diabetes and Offspring Fertility.Endocrinology · 2021Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence from literature is mixed regarding a possible association of maternal gestational diabetes mellitus (GDM) and overweight in the offspring. Sexual dimorphism, or sex disparities in the pathogenesis linking GDM exposure to overweight, could be at play. The objective of this study was to investigate the association between GDM and child overweight at 5-7 years. Six hundred pairs (1:1) of Reunionese liveborn singletons selected from a hospital-based birth registry, matched for sex, gestational age, and birth period, underwent a prospective in-home follow-up and were analyzed with respect to their exposure to GDM. The primary outcome was child overweight at 5-7 years, as defined by the International Obesity Task Force. The association between GDM exposure and child overweight was estimated by the odds ratio (OR) using conditional logistic regression models. For the subset of children exposed to GDM with available maternal glycemic data, we analyzed the relationship between maternal glycemic levels during pregnancy and child body mass index (BMI) at 5-7 years with a linear regression model. In light of the significant interaction between sex and GDM, all statistical analyses were then stratified by sex. After controlling for pre-pregnancy BMI and maternal sociodemographic characteristics, the risk of overweight increased with exposure to GDM for boys (adjusted OR: 2.34; 95% confidence interval = 1.26-4.34, P = 0.007) but not for girls (adjusted OR: 0.56; 95%CI = 0.28-1.10, P = 0.093). Consistent with this, the linear increase of boys' BMI at 5-7 years with maternal blood glucose levels during pregnancy, in the exposed group, displayed a dose-response relationship. Our findings indicate that exposure to GDM is a risk factor for childhood overweight in boys but not in girls, which adds to the growing body of evidence suggesting greater sensitivity of male offspring to intrauterine hyperglycemia.
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