ArticlePloS one2018
Trends in congenital anomalies in Europe from 1980 to 2012.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 2 of them syntheses that pooled it.
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Who cites it
64 citing papers in PubMed, 2 syntheses or guidelines pooled it, 160 citations in OpenAlex.
- Pooled it
- Association between birth location and short-term outcomes for babies with gastroschisis, congenital diaphragmatic hernia and oesophageal fistula: a systematic review.BMJ paediatrics open · 2023Pooled it
- Temporal trends and maternal factors associated with congenital anomalies among live births in São Paulo, Brazil: a population-based study, 2015-2023.BMC pregnancy and childbirth · 2026Article
- The Burden of Lower Limb Deformities in Low- and Lower-Middle-Income Countries: A Scoping Review.Journal of the Pediatric Orthopaedic Society of North America · 2026Review
- Genetic Diagnoses Among Congenital Anomaly Cases in Europe: Data From the EUROCAT Network.Paediatric and perinatal epidemiology · 2026Article
- A Population-Based Study of U.S. Trends in Selected Congenital Anomalies (2016-2023) and Socio-Demographic Disparities: A CDC WONDER Analysis.Children (Basel, Switzerland) · 2026Article
- Societal costs associated with mothers of children with major congenital anomalies: a population-based matched cohort study in Denmark.BMJ public health · 2026Article
- The influence of paternal preconception health on birth defects and head circumference: A scoping review.PLOS global public health · 2026Article
- The Impact of Advanced Maternal Age on Pregnancy Complications and Neonatal Outcomes.Journal of clinical medicine · 2025Article
- Patterns and Clinical Outcomes of Congenital Anomalies of the Kidney and Urinary Tract in Preterm Infants.Cureus · 2025Article
- Prevalence, Incidence, and Age at Diagnosis of Boys With Hypospadias: A Nationwide Population-Based Epidemiological Study.The Journal of urology · 2025Article
- Prevalence and trends of major congenital anomalies in Brazil: A study from 2011 to 2020.PloS one · 2025Article
- Article
- Temporal trends in the prevalence of major birth defects in China: a nationwide population-based study from 2007 to 2021.World journal of pediatrics : WJP · 2024Article
- Pathogenic PHIP Variants are Variably Associated With CAKUT.Kidney international reports · 2024Article
- The ten-year evaluation of clinical characteristics in congenital lung anomaly in pediatrics; a retrospective study in North of Iran.BMC pediatrics · 2024Article
- Epidemiology of congenital polydactyly and syndactyly in Hunan Province, China.BMC pregnancy and childbirth · 2024Article
- Association between maternal employment status and presence of children with major congenital anomalies in Denmark.BMC public health · 2024Article
- Prevalence of neural tube defects in England prior to the mandatory fortification of non-wholemeal wheat flour with folic acid: a population-based cohort study.Archives of disease in childhood · 2024Observational
- Prenatal Diagnosis, Associated Findings, and Postnatal Outcome in Fetuses with Double Inlet Ventricle (DIV).Ultraschall in der Medizin (Stuttgart, Germany : 1980) · 2023Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
30 authors at 20 institutions in 14 countries.
Funding
Abstract
backgroundSurveillance of congenital anomalies is important to identify potential teratogens.
methodsThis study analysed the prevalence of 61 congenital anomaly subgroups (excluding chromosomal) in 25 population-based EUROCAT registries (1980-2012). Live births, fetal deaths and terminations of pregnancy for fetal anomaly were analysed with multilevel random-effects Poisson regression models.
resultsSeventeen anomaly subgroups had statistically significant trends from 2003-2012; 12 increasing and 5 decreasing.
conclusionsThe annual increasing prevalence of severe congenital heart defects, single ventricle, atrioventricular septal defects and tetralogy of Fallot of 1.4% (95% CI: 0.7% to 2.0%), 4.6% (1.0% to 8.2%), 3.4% (1.3% to 5.5%) and 4.1% (2.4% to 5.7%) respectively may reflect increases in maternal obesity and diabetes (known risk factors). The increased prevalence of cystic adenomatous malformation of the lung [6.5% (3.5% to 9.4%)] and decreased prevalence of limb reduction defects [-2.8% (-4.2% to -1.5%)] are unexplained. For renal dysplasia and maternal infections, increasing trends may be explained by increased screening, and deceases in patent ductus arteriosus at term and increases in craniosynostosis, by improved follow up period after birth and improved diagnosis. For oesophageal atresia, duodenal atresia/stenosis and ano-rectal atresia/stenosis recent changes in prevalence appeared incidental when compared with larger long term fluctuations. For microcephaly and congenital hydronephrosis trends could not be interpreted due to discrepancies in diagnostic criteria. The trends for club foot and syndactyly disappeared once registries with disparate results were excluded. No decrease in neural tube defects was detected, despite efforts at prevention through folic acid supplementation.
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