Evidence map›Paper›PMID 29621199›Full record

ArticleViruses2018

Expert Opinion on Three Phage Therapy Related Topics: Bacterial Phage Resistance, Phage Training and Prophages in Bacterial Production Strains.

Christine Rohde, Grégory Resch, Jean-Paul Pirnay, Bob G Blasdel, Laurent Debarbieux, Daniel Gelman, Andrzej Górski, Ronen Hazan, Isabelle Huys, Elene Kakabadze and 13 more

Open access · goldAbstract readConference Proceedings
In one paragraph

Article in Viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed, 1 pooled it
15.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

134 citing papers in PubMed, 1 synthesis or guideline pooled it, 202 citations in OpenAlex.

  1. Pooled it
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  20. JAC-antimicrobial resistance · 2025
    Article

74 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 14 institutions in 11 countries.

Christine RohdeDepartment of Microorganisms, Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures, 38100 Braunschweig, Germany. Christine.Rohde@dsmz.de.
Grégory ReschDepartment of Fundamental Microbiology, University of Lausanne, 1015 Lausanne, Switzerland. Gregory.Resch@unil.ch.
Jean-Paul PirnayLaboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital, 1120 Brussels, Belgium. jean-paul.pirnay@mil.be.ORCID 0000-0002-6863-5219
Bob G BlasdelLaboratory of Gene Technology, Department of Biosystems, 3000 Leuven, Belgium. blasdelb@gmail.com.
Laurent DebarbieuxDepartment of Microbiology, Institut Pasteur, 75015 Paris, France. laurent.debarbieux@pasteur.fr.ORCID 0000-0001-6875-5758
Daniel GelmanFaculty of Dental Medicine, The Hebrew University of Jerusalem, Jerusalem 9112001, Israel. daniel.gelman@mail.huji.ac.il.
Andrzej GórskiBacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland. agorski@ikp.pl.
Ronen HazanFaculty of Dental Medicine, The Hebrew University of Jerusalem, Jerusalem 9112001, Israel. ronenh@ekmd.huji.ac.il.
Isabelle HuysDepartment of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium. isabelle.huys@kuleuven.be.
Elene KakabadzeEliava Institute of Bacteriophage, Microbiology and Virology, Gotua Street 3, 0160 Tbilisi, Georgia. elene.kakabadze@pha.ge.
Małgorzata ŁobockaInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, 00-901 Warsaw, Poland. lobocka@ibb.waw.pl.
Alice MaestriUniversity of Turin, 10124 Turin, Italy. alice.maestri@edu.unito.it.
Gabriel Magno de Freitas AlmeidaCentre of Excellence in Biological Interactions, Department of Biological and Environmental Science, Nanoscience Center, University of Jyväskylä, Survontie 9C, FI-40014 Jyväskylä, Finland. gabriel.m.almeida@jyu.fi.ORCID 0000-0003-2317-5092
Khatuna MakalatiaEliava Institute of Bacteriophage, Microbiology and Virology, Gotua Street 3, 0160 Tbilisi, Georgia. khatuna.makalatia@pha.ge.
Danish J MalikChemical Engineering Department, Loughborough University, Leicestershire LE11 3TU, UK. d.j.malik@lboro.ac.uk.
Ivana MašlaňováDepartment of Experimental Biology, Faculty of Science, Masaryk University, 60000 Brno, Czech Republic. iva.maslanova@gmail.com.
Maia MerabishviliLaboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital, 1120 Brussels, Belgium. maya.merabishvili@pha.ge.
Roman PantucekDepartment of Experimental Biology, Faculty of Science, Masaryk University, 60000 Brno, Czech Republic. pantucek@sci.muni.cz.ORCID 0000-0002-3950-675X
Thomas RoseLaboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital, 1120 Brussels, Belgium. thomas.rose@mil.be.
Dana ŠtverákováDepartment of Experimental Biology, Faculty of Science, Masaryk University, 60000 Brno, Czech Republic. stverakova@mbph.cz.
Hilde Van RaemdonckLaboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital, 1120 Brussels, Belgium. hilde.vanraemdonck@mil.be.
Gilbert VerbekenLaboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital, 1120 Brussels, Belgium. Gilbert.Verbeken@mil.be.
Nina ChanishviliEliava Institute of Bacteriophage, Microbiology and Virology, Gotua Street 3, 0160 Tbilisi, Georgia. nina.chanishvili@pha.ge.
Queen Astrid Military Hospital · BEGeorge Eliava Institute of Bacteriophage, Microbiology and Virology · GEMasaryk University · CZHebrew University of Jerusalem · ILKU Leuven · BEGhent University · BEInstitut Pasteur · FRLeibniz Institute DSMZ – German Collection of Microorganisms and Cell Cultures · DELoughborough University · GBMedical University of Warsaw · PLUniversity of Jyväskylä · FIUniversity of Lausanne · CHUniversity of Turin · ITWarsaw University of Life Sciences · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phage therapy is increasingly put forward as a "new" potential tool in the fight against antibiotic resistant infections. During the "Centennial Celebration of Bacteriophage Research" conference in Tbilisi, Georgia on 26-29 June 2017, an international group of phage researchers committed to elaborate an expert opinion on three contentious phage therapy related issues that are hampering clinical progress in the field of phage therapy. This paper explores and discusses bacterial phage resistance, phage training and the presence of prophages in bacterial production strains while reviewing relevant research findings and experiences. Our purpose is to inform phage therapy stakeholders such as policy makers, officials of the competent authorities for medicines, phage researchers and phage producers, and members of the pharmaceutical industry. This brief also points out potential avenues for future phage therapy research and development as it specifically addresses those overarching questions that currently call for attention whenever phages go into purification processes for application.

Indexed as

Phage TherapyAnimalsBacteriaBacterial InfectionsBacteriophagesEnvironmental MicrobiologyFood MicrobiologyHumansadaptationBacteriophagephage therapyproductionprophageregulationresistance

Identifiers

PMID29621199
PMCPMC5923472
OpenAlexW2796428137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.