ReviewInternational journal of molecular sciences2018
Emerging Roles of Estrogen-Related Receptors in the Brain: Potential Interactions with Estrogen Signaling.
Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 72 citations in OpenAlex.
- The Role and Mechanism of Estrogen in Perimenopausal Depression.Current neuropharmacology · 2026Review
- Review
- Kisspeptin as a marker for male infertility: a comparative study of serum and seminal plasma kisspeptin between fertile and infertile men.Journal of assisted reproduction and genetics · 2025Article
- Oestrogen Receptor Alpha in Myocyte Maintains Muscle Regeneration in Duchenne Muscular Dystrophy.Journal of cachexia, sarcopenia and muscle · 2025Article
- Silencing ofMolecular medicine reports · 2025Article
- Shaoyao Gancao decoction alleviates functional constipation by inhibitingFrontiers in cellular and infection microbiology · 2025Article
- Influence of endogenous and exogenous hormones on the cardiovascular response to lower extremity exercise and group III/IV activation in young females.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Sex as a Determinant of Age-Related Changes in the Brain.International journal of molecular sciences · 2024Review
- The bidirectional association between premenstrual disorders and perinatal depression: A nationwide register-based study from Sweden.PLoS medicine · 2024Article
- Investigations of microbiota composition and neuroactive pathways in association with symptoms of stress and depression in a cohort of healthy women.Frontiers in cellular and infection microbiology · 2024Article
- Ovarian hormones and eating disorders.Frontiers in psychology · 2024Review
- Modeling methamphetamine use disorder and relapse in animals: short- and long-term epigenetic, transcriptional., and biochemical consequences in the rat brain.Neuroscience and biobehavioral reviews · 2023Review
- Oral combined hormonal contraceptive associated with protection against allodynia in migraine in a cross-sectional study.Irish journal of medical science · 2023Article
- Multifaceted Transcriptional Network of Estrogen-Related Receptor Alpha in Health and Disease.International journal of molecular sciences · 2023Review
- Roles of Estrogen, Estrogen Receptors, and Estrogen-Related Receptors in Skeletal Muscle: Regulation of Mitochondrial Function.International journal of molecular sciences · 2023Review
- Role of sex hormones in diabetic nephropathy.Frontiers in endocrinology · 2023Review
- Zebrafish as an emerging model to study estrogen receptors in neural development.Frontiers in endocrinology · 2023Review
- Voluntary wheel running alters markers of amyloid-beta precursor protein processing in an ovarian hormone depleted model.Frontiers in endocrinology · 2022Article
- Estrogen-related Receptor Alpha (ERRα) is Required for PGC-1α-dependent Gene Expression in the Mouse Brain.Neuroscience · 2021Article
- Estradiol Protects against Noise-Induced Hearing Loss and Modulates Auditory Physiology in Female Mice.International journal of molecular sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In addition to their well-known role in the female reproductive system, estrogens can act in the brain to regulate a wide range of behaviors and physiological functions in both sexes. Over the past few decades, genetically modified animal models have greatly increased our knowledge about the roles of estrogen receptor (ER) signaling in the brain in behavioral and physiological regulations. However, less attention has been paid to the estrogen-related receptors (ERRs), the members of orphan nuclear receptors whose sequences are homologous to ERs but lack estrogen-binding ability. While endogenous ligands of ERRs remain to be determined, they seemingly share transcriptional targets with ERs and their expression can be directly regulated by ERs through the estrogen-response element embedded within the regulatory region of the genes encoding ERRs. Despite the broad expression of ERRs in the brain, we have just begun to understand the fundamental roles they play at molecular, cellular, and circuit levels. Here, we review recent research advancement in understanding the roles of ERs and ERRs in the brain, with particular emphasis on ERRs, and discuss possible cross-talk between ERs and ERRs in behavioral and physiological regulations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.