ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2018
Food withdrawal alters the gut microbiota and metabolome in mice.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
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- Arctigenin-containing burdock sprout extract prevents obesity in association with modulation of the gut microbiota in mice.Bioscience of microbiota, food and health · 2023Article
- Tauroursodeoxycholic acid (TUDCA) improves intestinal barrier function associated with TGR5-MLCK pathway and the alteration of serum metabolites and gut bacteria in weaned piglets.Journal of animal science and biotechnology · 2022Article
- Microbiota and body weight control: Weight watchers within?Molecular metabolism · 2022Review
- Native and Engineered Probiotics: Promising Agents against Related Systemic and Intestinal Diseases.International journal of molecular sciences · 2022Review
- Influence of pregnancy and non-fasting conditions on the plasma metabolome in a rat prenatal toxicity study.Archives of toxicology · 2021Article
- Impact of Different Durations of Fasting on Intestinal Autophagy and Serum Metabolome in Broiler Chicken.Animals : an open access journal from MDPI · 2021Article
- A Crosstalk between Diet, Microbiome and microRNA in Epigenetic Regulation of Colorectal Cancer.Nutrients · 2021Review
- Different enzymatic associations in diets of broiler chickens formulated with corn dried at various temperatures.Poultry science · 2021Article
- Hyocholic acid species as novel biomarkers for metabolic disorders.Nature communications · 2021Article
- The Metabolome of Carbapenem-Resistant Klebsiella pneumoniae Infection in Plasma.Disease markers · 2021Article
- Gut Microbiota Manipulation as a Tool for Colorectal Cancer Management: Recent Advances in Its Use for Therapeutic Purposes.International journal of molecular sciences · 2020Review
- Artificial microbiome heterogeneity spurs six practical action themes and examples to increase study power-driven reproducibility.Scientific reports · 2020Article
- Time of Feeding Alters Obesity-Associated Parameters and Gut Bacterial Communities, but Not Fungal Populations, in C57BL/6 Male Mice.Current developments in nutrition · 2020Article
- Recent advances in modulating the microbiome.F1000Research · 2020Review
- Impact of Different Types of Diet on Gut Microbiota Profiles and Cancer Prevention and Treatment.Medicina (Kaunas, Lithuania) · 2019Review
- Food withdrawal alters the gut microbiota and metabolome in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- The role of the gut microbiota on animal model reproducibility.Animal models and experimental medicine · 2018Review
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 2 countries.
Funding
Abstract
Food withdrawal as a health-enhancing measure has beneficial effects on aging, disease prevention, and treatment. However, the cellular and molecular mechanisms involving gut microbial changes and metabolic consequences resulting from food withdrawal have yet to be elucidated. In this study, we subjected lean and obese mice to a dietary intervention that consisted of a 4-d complete food withdrawal and an 8-d 50% food withdrawal, and we studied changes in cecal microbiome and host serum metabolome. The abundance of potentially pathogenic Proteobacteria was decreased and Akkermansia muciniphila was elevated by food withdrawal in mice fed a high-fat diet (HFD). Meanwhile, food withdrawal decreased the abundance of metabolites in branched chain amino acid, lipid, and free fatty acid metabolisms in host serum, more so in HFD mice than in normal mice. Microbial predicted function also showed that food withdrawal decreased the abundance of microbes associated with predicted diseases in the HFD group but not in the normal chow group. Correlation between the microbiome data and metabolomics data revealed a strong association between gut microbial and host metabolic changes in response to food withdrawal. In summary, our results showed that food withdrawal was safer and more metabolically beneficial to HFD-induced obese mice than to normal lean mice, and the beneficial effects were primarily derived from the changes in gut microbiota, which were closely associated with the host metabolome.-Zheng, X., Zhou, K., Zhang, Y., Han, X., Zhao, A., Liu, J., Qu, C., Ge, K., Huang, F., Hernandez, B., Yu, H., Panee, J., Chen, T., Jia, W., Jia, W. Food withdrawal alters the gut microbiota and metabolome in mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.