ArticleACS applied materials & interfaces2018
Biofunctionalized 3D Nanopillar Arrays Fostering Cell Guidance and Promoting Synapse Stability and Neuronal Activity in Networks.
Article in ACS applied materials & interfaces, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Vertically Aligned Nanopillar Electrodes: Engineered Interfaces for Electrophysiology and Cell-Electrode Coupling.Small methods · 2026Review
- Review
- Longitudinal and Noninvasive Intracellular Recordings of Spontaneous Electrophysiological Activity in Rat Primary Neurons on Planar MEA Electrodes.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Advances in human amniotic placenta membrane-derived mesenchymal stromal cells (hAMSCs) for regenerative medicine: enhancing therapeutic potential with biomaterials and scaffolds.Frontiers in bioengineering and biotechnology · 2025Review
- Beyond a Transmission Cable-New Technologies to Reveal the Richness in Axonal Electrophysiology.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Flexible metallic core-shell nanostructured electrodes for neural interfacing.Scientific reports · 2024Article
- Streamlining the interface between electronics and neural systems for bidirectional electrochemical communication.Chemical science · 2023Review
- Passive Recording of Bioelectrical Signals from Non-Excitable Cells by Fluorescent Mirroring.Nano letters · 2023Article
- Advances in Cell-Conductive Polymer Biointerfaces and Role of the Plasma Membrane.Chemical reviews · 2022Article
- Recent progresses in novelFrontiers in bioengineering and biotechnology · 2022Review
- Tutorial: using nanoneedles for intracellular delivery.Nature protocols · 2021Review
- Anisometric Microstructures to Determine Minimal Critical Physical Cues Required for Neurite Alignment.Advanced healthcare materials · 2021Article
- Nanoparticle and Biomolecule Surface Modification Synergistically Increases Neural Electrode Recording Yield and Minimizes Inflammatory Host Response.Advanced healthcare materials · 2021Article
- A microfabricated multi-compartment device for neuron and Schwann cell differentiation.Scientific reports · 2021Article
- Electrophysiology Read-Out Tools for Brain-on-Chip Biotechnology.Micromachines · 2021Review
- Recent advances in bioelectronics chemistry.Chemical Society reviews · 2020Review
- Neurite guidance and neuro-caging on steps and grooves in 2.5 dimensions.Nanoscale advances · 2020Article
- High-Aspect-Ratio Nanostructured Surfaces as Biological Metamaterials.Advanced materials (Deerfield Beach, Fla.) · 2020Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A controlled geometry of in vitro neuronal networks allows investigation of the cellular mechanisms that underlie neuron-to-neuron and neuron-extracellular matrix interactions, which are essential to biomedical research. Herein, we report a selective guidance of primary hippocampal neurons by using arrays of three-dimensional vertical nanopillars (NPs) functionalized with a specific adhesion-promoting molecule-poly-dl-ornithine (PDLO). We show that 90% of neuronal cells are guided exclusively on the combinatorial PDLO/NP substrate. Moreover, we demonstrate the influence of the interplay between nanostructures and neurons on synapse formation and maturation, resulting in increased expression of postsynaptic density-95 protein and enhanced network cellular activity conferred by the endogenous c-fos expression. Successful guidance to foster synapse stability and cellular activity on multilevel cues of surface topography and chemical functionalization suggests the potential to devise technologies to control neuronal growth on nanostructures for tissue engineering, neuroprostheses, and drug development.
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Registered trials
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