Evidence map›Paper›PMID 29620523›Full record

ArticleeLife2018

An incoherent feedforward loop facilitates adaptive tuning of gene expression.

Jungeui Hong, Nathan Brandt, Farah Abdul-Rahman, Ally Yang, Tim Hughes, David Gresham

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Jungeui HongDepartment of Biology, Center for Genomics and Systems Biology, New York University, New York, United States.
Nathan BrandtDepartment of Biology, Center for Genomics and Systems Biology, New York University, New York, United States.
Farah Abdul-RahmanDepartment of Biology, Center for Genomics and Systems Biology, New York University, New York, United States.
Ally YangBanting and Best Department of Medical Research, Donnelly Centre, University of Toronto, Toronto, Canada.
Tim HughesBanting and Best Department of Medical Research, Donnelly Centre, University of Toronto, Toronto, Canada.
David GreshamDepartment of Biology, Center for Genomics and Systems Biology, New York University, New York, United States.ORCID http://orcid.org/0000-0002-4028-0364
New York University · USUniversity of Toronto · CAMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Regulation of Quiescence in Eukaryotic CellsR01GM107466 · NIGMS · NEW YORK UNIVERSITY · PI GRESHAM, DAVID · 2013 to 2022
$3.0M
NCI NIH HHS P30 CA008748NIGMS NIH HHS R01 GM107466NIH HHS R01GM107466
6 · The paper itself

Abstract

We studied adaptive evolution of gene expression using long-term experimental evolution of

Indexed as

Gene Expression Regulation, FungalGene Regulatory NetworksModels, TheoreticalMutationPromoter Regions, GeneticProtein BindingSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSignal TransductionTranscription FactorsSaccharomyces cerevisiae ProteinsTranscription Factorsevolutionary biologyexperimental evolutiongene expressiongenomicsS. cerevisiaetranscription factors

Identifiers

PMID29620523
PMCPMC5903863
OpenAlexW2796240499

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.