ArticleMolecular medicine reports2018
Curcumol attenuates epithelial-mesenchymal transition of nasopharyngeal carcinoma cells via TGF-β1.
Article in Molecular medicine reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 21 citations in OpenAlex.
- Curcumol Inhibits the Laminin-Facilitated Malignant Progression in Small-Cell Lung Cancer via Disrupting Laminin-Integrin β1 Interaction.Phytotherapy research : PTR · 2026Article
- Multi-Omics Exploration of the Mechanism of Curcumol to Reduce Invasion and Metastasis of Nasopharyngeal Carcinoma by Inhibiting NCL/EBNA1-Mediated UBE2C Upregulation.Biomolecules · 2024Article
- Curcumol: a review of its pharmacology, pharmacokinetics, drug delivery systems, structure-activity relationships, and potential applications.Inflammopharmacology · 2024Review
- Role of Curcuma longae Rhizoma in medical applications: research challenges and opportunities.Frontiers in pharmacology · 2024Review
- Degradation of HIF-1α induced by curcumol blocks glutaminolysis and inhibits epithelial-mesenchymal transition and invasion in colorectal cancer cells.Cell biology and toxicology · 2023Article
- Analysis on internal mechanism of zedoary turmeric in treatment of liver cancer based on pharmacodynamic substances and pharmacodynamic groups.Chinese herbal medicines · 2022Review
- Curcumol inhibits the growth of xenograft-tumors in mice and the biological activities of pancreatic cancer cells by regulating the miR-21-5p/SMAD7 axis.Cell cycle (Georgetown, Tex.) · 2022Article
- Curcumol Inhibits the Development of Prostate Cancer by miR-125a/STAT3 Axis.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Curcumol repressed cell proliferation and angiogenesisFrontiers in pharmacology · 2022Article
- Curcumol increases the sensitivity of colon cancer to 5-FU by regulating Wnt/β-catenin signaling.Translational cancer research · 2021Article
- Curcumol inhibits the viability and invasion of colorectal cancer cells via miR-30a-5p and Hippo signaling pathway.Oncology letters · 2021Article
- Curcumol Ameliorates Lung Inflammation and Airway Remodeling via Inhibiting the Abnormal Activation of the Wnt/β-Catenin Pathway in Chronic Asthmatic Mice.Drug design, development and therapy · 2021Article
- Curcumol enhances the anti-tumor effects of metformin via suppressing epithelial-mesenchymal transition in triple-negative breast cancer.Annals of translational medicine · 2020Article
- Overexpression of BMP‑7 reverses TGF‑β1‑induced epithelial‑mesenchymal transition by attenuating the Wnt3/β‑catenin and TGF-β1/Smad2/3 signaling pathways in HK‑2 cells.Molecular medicine reports · 2020Article
- Study on the Drug Targets and Molecular Mechanisms ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Curcumol inhibits the proliferation and metastasis of melanoma via the miR-152-3p/PI3K/AKT and ERK/NF-κB signaling pathways.Journal of Cancer · 2020Article
- Curcumol: From Plant Roots to Cancer Roots.International journal of biological sciences · 2019Review
- Curcumin and Curcumol Inhibit NF-Evidence-based complementary and alternative medicine : eCAM · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The current study aimed to identify the effect and primary mechanism of Curcumol on the migration of nasopharyngeal carcinoma (NPC) cells in vitro and in vivo. Curcumol was dissolved in absolute ethyl alcohol and the experiment was performed in NPC 5‑8F cells in vitro and in vivo. The effect of different concentrations of Curcumol on cell migration was determined using wound healing and Transwell assays. A cell counting kit‑8 (CCK‑8) assay was also performed in order to determine cell viability. Flow cytometry was used to detect the effect of Curcumol on apoptosis. The expression of epithelial‑mesenchymal transition (EMT)‑associated proteins and genes was evaluated by western blotting, reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) and ELISA. In addition, the antitumor activity of Curcumol was investigated in female BALB/C nude mice with orthotopic tumor implants. The results indicated that cell apoptosis was increased and the viability of NPC 5‑8F cells was decreased following treatment with Curcumol at doses of 0.1, 0.2 and 0.4 µM/ml. The results of in vivo experiments indicated that tumor growth and weight were decreased following Curcumol administration. Furthermore, the results of western blotting and RT‑qPCR demonstrated that Curcumol altered the level of E‑cadherin and N‑cadherin in a dose‑dependent manner in vivo. Curcumol also regulated the secretion of protein markers in the serum that were associated with EMT and TGF‑β1 in the 5‑8F xenograft mouse model. Thus, the results indicated that Curcumol induced TGF‑β1‑mediated EMT arrest by regulating E‑cadherin and N‑cadherin, which may prevent further development of NPC.
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