ArticleInternational journal of molecular medicine2018
Low‑intensity pulsed ultrasound promotes periodontal ligament stem cell migration through TWIST1‑mediated SDF‑1 expression.
Article in International journal of molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Recent Advances in Basic Studies of Low-Intensity Pulsed Ultrasound in Periodontal Tissue Regeneration: A Systematic Review.Stem cell reviews and reports · 2024Pooled it
- Low-intensity pulsed ultrasound alleviates periodontitis in mice with T2DM through Nrf2 pathway.APL bioengineering · 2025Article
- Ultrasound-responsive hydrogels for bone and cartilage tissue engineering.Materials today. Bio · 2025Review
- [Advances of low-intensity pulsed ultrasound for treatment of musculoskeletal disorders in the past decade].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Review
- [Regenerative rehabilitation: the effects of physical factors on regeneration].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2024Article
- Article
- Sonomechanobiology: Vibrational stimulation of cells and its therapeutic implications.Biophysics reviews · 2023Review
- Low-intensity pulsed ultrasound enhances immunomodulation and facilitates osteogenesis of human periodontal ligament stem cells by inhibiting the NF-κB pathway.Cell and tissue banking · 2023Article
- Remote control of the recruitment and capture of endogenous stem cells by ultrasound for in situ repair of bone defects.Bioactive materials · 2023Article
- Application of low-intensity pulsed ultrasound on tissue resident stem cells: Potential for ophthalmic diseases.Frontiers in endocrinology · 2023Review
- LIPUS-S/B@NPs regulates the release of SDF-1 and BMP-2 to promote stem cell recruitment-osteogenesis for periodontal bone regeneration.Frontiers in bioengineering and biotechnology · 2023Article
- LIPUS as a potential strategy for periodontitis treatment: A review of the mechanisms.Frontiers in bioengineering and biotechnology · 2023Review
- Biomimetic Tubular Matrix Induces Periodontal Ligament Principal Fiber Formation and Inhibits Osteogenic Differentiation of Periodontal Ligament Stem Cells.ACS applied materials & interfaces · 2022Article
- Knee Loading Enhances the Migration of Adipose-Derived Stem Cells to the Osteoarthritic Sites Through the SDF-1/CXCR4 Regulatory Axis.Calcified tissue international · 2022Article
- Advances in the application of low-intensity pulsed ultrasound to mesenchymal stem cells.Stem cell research & therapy · 2022Review
- Effectiveness and Mechanisms of Low-Intensity Pulsed Ultrasound on Osseointegration of Dental Implants and Biological Functions of Bone Marrow Mesenchymal Stem Cells.Stem cells international · 2022Review
- Low-intensity pulsed ultrasound attenuates replacement root resorption of avulsed teeth stored in dry condition in dogs.Scientific reports · 2021Article
- Symmetry breaking of tissue mechanics in wound induced hair follicle regeneration of laboratory and spiny mice.Nature communications · 2021Article
- Bioinformatics Analysis Identified miR-584-5p and Key miRNA-mRNA Networks Involved in the Osteogenic Differentiation of Human Periodontal Ligament Stem Cells.Frontiers in genetics · 2021Article
- Propagating acoustic waves on a culture substrate regulate the directional collective cell migration.Microsystems & nanoengineering · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low‑intensity pulsed ultrasound (LIPUS) is a non‑invasive therapeutic treatment for accelerating fracture healing. A previous study from our group demonstrated that LIPUS has the potential to promote periodontal tissue regeneration. However, the underlying molecular mechanism by which LIPUS promotes periodontal tissue regeneration remains unknown. In the present study, periodontal ligament stem cells (PDLSCs) were isolated from premolars. Flow cytometry and differentiation assays were used to characterize the isolated PDLSCs. LIPUS treatment was administered to PDLSCs, and stromal cell‑derived factor‑1 (SDF‑1) expression levels were examined by reverse transcription‑quantitative polymerase chain reaction with or without blocking the SDF‑1/C‑X‑C motif chemokine receptor 4 (CXCR4) pathway with AMD3100. ELISA was used to evaluate SDF‑1 secretion in PDLSCs. Wound healing and transwell assays were conducted to assess the migration‑promoting effect of LIPUS. A potential upstream gene of SDF‑1, twist family bHLH transcription factor 1 (TWIST1), was silenced by small interfering (si) RNA transfection. The results demonstrated that LIPUS treatment promoted the expression of TWIST1 and SDF‑1 at both the mRNA and protein levels. In addition, LIPUS treatment enhanced the cell migration of PDLSCs. Knockdown of TWIST1 impaired the expression of SDF‑1 and the cell migration ability of PDLSCs. TWIST1 may be an upstream regulator of SDF‑1 in PDLSCs. Taken together, these findings indicate that the SDF1/CXCR4 signaling pathway is involved in LIPUS‑promoted PDLSC migration, which might be one of the mechanisms for LIPUS‑mediated periodontal regeneration. TWIST1 might be a mechanical stress sensor during mechanotransduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.