Observational studyInternal and emergency medicine2018
Multiple hormonal and metabolic deficiency syndrome in chronic heart failure: rationale, design, and demographic characteristics of the T.O.S.CA. Registry.
Observational study in Internal and emergency medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02335801 (The TOSCA Registry), which is not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The TOSCA Registry: Epidemiology, Clinical and Prognostic Value of Hormonal and Metabolic Deficiencies in Chronic Heart Failure
Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- Risk calculator of multimorbid risk of rehospitalization and death from heart failure: including the contribution of the gut microbiome.European journal of preventive cardiology · 2026Article
- The Association Between Chronic Heart Failure and Metabolic Syndrome Increases the Cost of Hospitalization.Healthcare (Basel, Switzerland) · 2025Article
- Sarcopenia and it's influencing factors among adults with asthma, chronic obstructive pulmonary disease, and tuberculosis in Penang, Malaysia.BMC public health · 2025Article
- Subclinical hypothyroidism predicts outcome in heart failure: insights from the T.O.S.CA. registry.Internal and emergency medicine · 2024Observational
- Chinese Medicine Supplementing Qi and Activating Blood Circulation Relieves the Progression of Diabetic CardiomyopathyEndocrine, metabolic & immune disorders drug targets · 2024Article
- Sarcopenia and Cardiovascular Diseases.Circulation · 2023Review
- Testosterone deficiency independently predicts mortality in women with HFrEF: insights from the T.O.S.CA. registry.ESC heart failure · 2023Observational
- Sarcopenia: Inflammatory and Humoral Markers in Older Heart Failure Patients.Arquivos brasileiros de cardiologia · 2023Article
- Insulin-like growth factor-1 (IGF-1) as predictor of cardiovascular mortality in heart failure patients: data from the T.O.S.CA. registry.Internal and emergency medicine · 2022Article
- Progressive right ventricular dysfunction and exercise impairment in patients with heart failure and diabetes mellitus: insights from the T.O.S.CA. Registry.Cardiovascular diabetology · 2022Article
- Muscle Wasting and Sarcopenia in Heart Failure-The Current State of Science.International journal of molecular sciences · 2020Review
- Heart failure management during the COVID-19 outbreak in Italy: a telemedicine experience from a heart failure university tertiary referral centre.European journal of heart failure · 2020Article
- Sarcopenia and Heart Failure.Nutrients · 2020Review
- Anabolic Hormones Deficiencies in Heart Failure With Preserved Ejection Fraction: Prevalence and Impact on Antioxidants Levels and Myocardial Dysfunction.Frontiers in endocrinology · 2020Article
- Combined effects of growth hormone and testosterone replacement treatment in heart failure.ESC heart failure · 2019Article
- Risk stratification in hospitalized heart failure patients: do the RIGHT thing!Internal and emergency medicine · 2019Article
- Article
- Multiple hormone deficiency syndrome: a novel topic in chronic heart failure.Future science OA · 2018Article
- Biomarkers in Heart Failure and Associated Diseases.Disease markersArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors at 16 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent evidence supports the concept that progression of chronic heart failure (CHF) depends upon an imbalance of catabolic forces over the anabolic drive. In this regard, multiple hormonal deficiency syndrome (MHDS) significantly has impacts upon CHF progression, and is associated with a worse clinical status and increased mortality. The T.O.S.CA. (Trattamento Ormonale nello Scompenso CArdiaco; Hormone Therapy in Heart Failure) Registry (clinicaltrial.gov = NCT02335801) tests the hypothesis that anabolic deficiencies reduce survival in a large population of mild-to-moderate CHF patients. The T.O.S.CA. Registry is a prospective multicenter observational study coordinated by "Federico II" University of Naples, and involves 19 centers situated throughout Italy. Thyroid hormones, insulin-like growth factor-1, total testosterone, dehydroepiandrosterone , and insulin are measured at baseline and every year for a patient-average follow-up of 3 years. Subjects with CHF are divided into two groups: patients with one or no anabolic deficiency, and patients with two or more anabolic deficiencies at baseline. The primary endpoint is the composite of all-cause mortality and cardiovascular hospitalization. Secondary endpoints include the composite of all-cause mortality and hospitalization, the composite of cardiovascular mortality and cardiovascular hospitalization, and change of VO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.