Evidence map›Paper›PMID 29619516›Full record

ArticleEuropean radiology2018

Hippocampal calcification on brain CT: prevalence and risk factors in a cerebrovascular cohort.

Remko Kockelkoren, Jill B De Vis, M Stavenga, Willem P Th M Mali, Jeroen Hendrikse, Annemieke M Rozemuller, Huiberdina L Koek, Irene C van der Schaaf, Birgitta K Velthuis, Pim A de Jong and 1 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Remko KockelkorenDepartment of Radiology, University Medical Center, Room E01.132, PO Box 85500, 3508 GA, Utrecht, The Netherlands. r.kockelkoren@umcutrecht.nl.ORCID http://orcid.org/0000-0001-5208-5534
Jill B De VisDepartment of Radiology, Johns Hopkins Medical Center, Baltimore, MD, USA.
M StavengaDepartment of Radiology, University Medical Center, Room E01.132, PO Box 85500, 3508 GA, Utrecht, The Netherlands.
Willem P Th M MaliDepartment of Radiology, University Medical Center, Room E01.132, PO Box 85500, 3508 GA, Utrecht, The Netherlands.
Jeroen HendrikseDepartment of Radiology, University Medical Center, Room E01.132, PO Box 85500, 3508 GA, Utrecht, The Netherlands.
Annemieke M RozemullerDepartment of Pathology, University Medical Center, Utrecht, The Netherlands.
Huiberdina L KoekDepartment of Geriatrics, University Medical Center, Utrecht, The Netherlands.
Irene C van der SchaafDepartment of Radiology, University Medical Center, Room E01.132, PO Box 85500, 3508 GA, Utrecht, The Netherlands.
Birgitta K VelthuisDepartment of Radiology, University Medical Center, Room E01.132, PO Box 85500, 3508 GA, Utrecht, The Netherlands.
Pim A de JongDepartment of Radiology, University Medical Center, Room E01.132, PO Box 85500, 3508 GA, Utrecht, The Netherlands.
DUST study group
Utrecht University · NLJohns Hopkins University · USUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesRecently, hippocampal calcification as observed on brain CT examinations was identified in over 20% of people over 50 years of age and a relation between hippocampal calcification and cognitive decline was shown. We determined the prevalence and investigated the vascular risk factors of hippocampal calcification in patients with cerebrovascular disease.

methodsHippocampal calcification was scored bilaterally on presence and severity on CT examinations in a cohort of 1130 patients with (suspected) acute ischaemic stroke. Multivariable logistic regression analysis, adjusting for age and gender as well as adjusting for multiple cardiovascular disease risk factors, was used to determine risk factors for hippocampal calcification.

resultsHippocampal calcification was present in 381 (34%) patients. Prevalence increased with age from 8% below 40 to 45% at 80 years and older. In multivariable logistic regression analysis, age per decile (OR 1.41 [95% CI 1.26-1.57], p < 0.01), hypertension (OR 0.74 [95% CI 0.56-0.99], p = 0.049), diabetes mellitus (OR 1.57 [95% CI 1.10-2.25], p = 0.01) and hyperlipidaemia (OR 1.63 [95% CI 1.20-2.22], p < 0.01) were significantly associated with hippocampal calcification.

conclusionsHippocampal calcification was a frequent finding on CT in this cohort of stroke patients and was independently positively associated with hyperlipidaemia and diabetes mellitus, suggesting an atherosclerotic origin. KEY POINTS: • Hippocampal calcification is prevalent in over 30% of cerebrovascular disease patients. • Prevalence increases from 8% below 40 to 45% over 80 years. • Hippocampal calcification is associated with cardiovascular risk factors hyperlipidaemia and diabetes mellitus.

Indexed as

AgedCalcinosisCerebrovascular DisordersCohort StudiesComorbidityFemaleHippocampusHumansMaleNetherlandsNeuroimagingPrevalenceProspective StudiesRisk FactorsSeverity of Illness IndexTomography, X-Ray ComputedHippocampusPrevalenceRisk factorsStrokeVascular calcification

Identifiers

PMID29619516
PMCPMC6096610
OpenAlexW2801078448

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.