Evidence map›Paper›PMID 29619344›Full record

ReviewFrontiers in oncology2018

The Predictive Value of Inflammation-Related Peripheral Blood Measurements in Cancer Staging and Prognosis.

Joanna L Sylman, Annachiara Mitrugno, Michelle Atallah, Garth W Tormoen, Joseph J Shatzel, Samuel Tassi Yunga, Todd H Wagner, John T Leppert, Parag Mallick, Owen J T McCarty

Abstract readReview
In one paragraph

Review in Frontiers in oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Prognostic Significance of the Pretreatment Neutrophil-to-Lymphocyte Ratio and Tumor-Associated Neutrophils in Head and Neck Squamous Cell Carcinoma: Systematic Review and Meta-Analysis.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Observational
  5. Article
  6. Review
  7. Beyond tumor biology: nursing interventions for psychological and immune health in cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Review
  8. Article
  9. Review
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  20. Review

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Joanna L SylmanVA Palo Alto Health Care System, Palo Alto, CA, United States.
Annachiara MitrugnoBiomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, OR, United States.
Michelle AtallahCanary Center at Stanford, Department of Radiology, Stanford University School of Medicine, Stanford, CA, United States.
Garth W TormoenDepartment of Radiation Medicine, Oregon Health & Science University, Portland, OR, United States.
Joseph J ShatzelDivision of Hematology and Medical Oncology, Oregon Health & Science University, Portland, OR, United States.
Samuel Tassi YungaCancer Early Detection & Advanced Research Center, Oregon Health & Science University, Portland, OR, United States.
Todd H WagnerVA Palo Alto Health Care System, Palo Alto, CA, United States.
John T LeppertVA Palo Alto Health Care System, Palo Alto, CA, United States.
Parag MallickCanary Center at Stanford, Department of Radiology, Stanford University School of Medicine, Stanford, CA, United States.
Owen J T McCartyBiomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, OR, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this review, we discuss the interaction between cancer and markers of inflammation (such as levels of inflammatory cells and proteins) in the circulation, and the potential benefits of routinely monitoring these markers in peripheral blood measurement assays. Next, we discuss the prognostic value and limitations of using inflammatory markers such as neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios and C-reactive protein measurements. Furthermore, the review discusses the benefits of combining multiple types of measurements and longitudinal tracking to improve staging and prognosis prediction of patients with cancer, and the ability of novel

Indexed as

biomarkerscancerC-reactive proteinlongitudinalneutrophil-to-lymphocyteplatelet-to-lymphocyteprognosis

Identifiers

PMID29619344
PMCPMC5871812

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.