Evidence map›Paper›PMID 29619317›Full record

ArticleNeuroImage. Clinical2018

Influence of inter-stimulus interval of spinal cord stimulation in patients with disorders of consciousness: A preliminary functional near-infrared spectroscopy study.

Yujin Zhang, Yi Yang, Juanning Si, Xiaoyu Xia, Jianghong He, Tianzi Jiang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Yujin ZhangBrainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
Yi YangDepartment of Neurosurgery, PLA Army General Hospital, Beijing 100700, China.
Juanning SiBrainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
Xiaoyu XiaDepartment of Neurosurgery, PLA Army General Hospital, Beijing 100700, China.
Jianghong HeDepartment of Neurosurgery, PLA Army General Hospital, Beijing 100700, China. Electronic address: he_jianghong@sina.cn.
Tianzi JiangBrainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 625014, China; CAS Center for Excellence in Brain Science, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; Queensland Brain Institute, University of Queensland, St. Lucia, Queensland 4072, Australia. Electronic address: jiangtz@nlpr.ia.ac.cn.
The Military General Hospital of Beijing PLA · CNInstitute of Automation · CNUniversity of Electronic Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord stimulation (SCS) is a promising treatment for disorders of consciousness (DOC), but the underlying mechanism and most effective procedures remain uncertain. To optimize the protocol, previous studies evaluated the frequency-specific effects of SCS on neurophysiological activities. However, whether and how the inter-stimulus interval (ISI) parameter affects the SCS neuromodulation in DOC remains unknown. We enrolled nine DOC patients who had implanted SCS devices and conducted three different durations of ISIs. Using functional near-infrared spectroscopy (fNIRS), we monitored the blood volume fluctuations in the prefrontal and occipital cortices during the SCS. The results showed that short stimuli (30 s) induced significant cerebral blood volume changes, especially in the prefrontal cortex, an important area in the consciousness system. By comparing the mean value of the responses from the first and the last block in each session, a shorter ISI was found to improve the blood volume in the prefrontal cortex. This phenomenon was more significant for the subgroup of patients with a favorable prognosis. These preliminary results imply that the ISI may be an important factor for SCS. The research paradigm proposed here also provides insights for further quantitative evaluations of the therapeutic effects of neuromodulation.

Indexed as

AdolescentAdultBrainChildConsciousness DisordersFemaleGlasgow Outcome ScaleHemodynamicsHumansMaleMiddle AgedSpectroscopy, Near-InfraredSpinal Cord StimulationTime FactorsYoung AdultARAS, ascending reticular activating systemCBF, cerebral blood flowDBS, deep brain stimulationDisorders of consciousnessDOC, disorders of consciousnessEEG, electroencephalographyfMRI, functional magnetic resonance imagingfNIRS, functional near-infrared spectroscopyFunctional near-infrared spectroscopyFWHM, full-width-at-half-maximumGOS, Glasgow Outcome ScaleHbO, oxygenated hemoglobinHbR, deoxygenated hemoglobinHbT, total hemoglobinInter-stimulus intervalISI, inter-stimulus intervalJFKCRS-R, JFK Coma Recovery ScaleLTP, long-term potentiationMBLL, modified Beer-Lambert lawMCS, minimally conscious stateMSN, medium spiny neuronPrefrontal cortexrCBV, regional cerebral blood volumeSCS, spinal cord stimulationSpinal cord stimulationTMS, transcranial magnetic stimulationVS, vegetative state

Identifiers

PMID29619317
PMCPMC5883216
OpenAlexW2757024287

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.