ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2018
Vertical Hydrodynamic Focusing and Continuous Acoustofluidic Separation of Particles via Upward Migration.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Acoustofluidic Biosensors.Micromachines · 2026Review
- A Review of SAW-Based Micro- and Nanoparticle Manipulation in Microfluidics.Sensors (Basel, Switzerland) · 2025Review
- Acoustic Waves Coupling with Polydimethylsiloxane in Reconfigurable Acoustofluidic Platform.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Acoustofluidic separation of prolate and spherical micro-objects.Microsystems & nanoengineering · 2024Article
- A review of acoustofluidic separation of bioparticles.Biophysical reviews · 2023Review
- Acoustofluidic separation of proteins from platelets in human blood plasma using aptamer-functionalized microparticles.Biomicrofluidics · 2023Article
- Direct separation and enumeration of CTCs in viscous blood based on co-flow microchannel with tunable shear rate: a proof-of-principle study.Analytical and bioanalytical chemistry · 2022Article
- Nanogap Electrode-Enabled Versatile Electrokinetic Manipulation of Nanometric Species in Fluids.Biosensors · 2022Article
- Recent advances in acoustofluidic separation technology in biology.Microsystems & nanoengineering · 2022Review
- Fabrication of tunable, high-molecular-weight polymeric nanoparticlesLab on a chip · 2021Article
- A disposable acoustofluidic chip for nano/microparticle separation using unidirectional acoustic transducers.Lab on a chip · 2020Article
- A localized surface acoustic wave applied spatiotemporally controllable chemical gradient generator.Biomicrofluidics · 2020Article
- Cell Adhesion, Morphology, and Metabolism Variation via Acoustic Exposure within Microfluidic Cell Handling Systems.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Dielectrophoresis Multipath Focusing of Microparticles through Perforated Electrodes in Microfluidic Channels.Biosensors · 2019Article
- Microparticle self-assembly induced by travelling surface acoustic waves.RSC advances · 2019Article
- Light-Ultrasound Driven Collective "Firework" Behavior of Nanomotors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2018Article
- Vertical Hydrodynamic Focusing and Continuous Acoustofluidic Separation of Particles via Upward Migration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A particle suspended in a fluid within a microfluidic channel experiences a direct acoustic radiation force (ARF) when traveling surface acoustic waves (TSAWs) couple with the fluid at the Rayleigh angle, thus producing two components of the ARF. Most SAW-based microfluidic devices rely on the horizontal component of the ARF to migrate prefocused particles laterally across a microchannel width. Although the magnitude of the vertical component of the ARF is more than twice the magnitude of the horizontal component, it is long ignored due to polydimethylsiloxane (PDMS) microchannel fabrication limitations and difficulties in particle focusing along the vertical direction. In the present work, a single-layered PDMS microfluidic chip is devised for hydrodynamically focusing particles in the vertical plane while explicitly taking advantage of the horizontal ARF component to slow down the selected particles and the stronger vertical ARF component to push the particles in the upward direction to realize continuous particle separation. The proposed particle separation device offers high-throughput operation with purity >97% and recovery rate >99%. It is simple in its fabrication and versatile due to the single-layered microchannel design, combined with vertical hydrodynamic focusing and the use of both the horizontal and vertical components of the ARF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.