Evidence map›Paper›PMID 29619277›Full record

ArticleJournal of pathology informatics2018

Deep Learning Nuclei Detection in Digitized Histology Images by Superpixels.

Sudhir Sornapudi, Ronald Joe Stanley, William V Stoecker, Haidar Almubarak, Rodney Long, Sameer Antani, George Thoma, Rosemary Zuna, Shelliane R Frazier

Abstract read
In one paragraph

Article in Journal of pathology informatics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

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  6. LAMA: Lesion-Aware Mixup Augmentation for Skin Lesion Segmentation.Journal of imaging informatics in medicine · 2024
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  15. Objective evaluation of chondrocyte density & cloning after joint injury using convolutional neural networks.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sudhir SornapudiDepartment of Electrical and Computer Engineering, Missouri University of Science and Technology, Rolla, USA.
Ronald Joe StanleyDepartment of Electrical and Computer Engineering, Missouri University of Science and Technology, Rolla, USA.
William V StoeckerStoecker and Associates, Rolla MO, USA.
Haidar AlmubarakDepartment of Electrical and Computer Engineering, Missouri University of Science and Technology, Rolla, USA.
Rodney LongDHHS, Lister Hill National Center for Biomedical Communications for National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
Sameer AntaniDHHS, Lister Hill National Center for Biomedical Communications for National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
George ThomaDHHS, Lister Hill National Center for Biomedical Communications for National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
Rosemary ZunaDepartment of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Shelliane R FrazierDepartment of Surgical Pathology, University of Missouri Hospitals and Clinics, Columbia, USA.

Funding

Image analysis and machine learning for cervical cancer diagnosticsZIALM010014 · NLM · NATIONAL LIBRARY OF MEDICINE · PI ANTANI, SAMEER · 2018 to 2020
$1.7M
6 · The paper itself

Abstract

backgroundAdvances in image analysis and computational techniques have facilitated automatic detection of critical features in histopathology images. Detection of nuclei is critical for squamous epithelium cervical intraepithelial neoplasia (CIN) classification into normal, CIN1, CIN2, and CIN3 grades.

methodsIn this study, a deep learning (DL)-based nuclei segmentation approach is investigated based on gathering localized information through the generation of superpixels using a simple linear iterative clustering algorithm and training with a convolutional neural network.

resultsThe proposed approach was evaluated on a dataset of 133 digitized histology images and achieved an overall nuclei detection (object-based) accuracy of 95.97%, with demonstrated improvement over imaging-based and clustering-based benchmark techniques.

conclusionsThe proposed DL-based nuclei segmentation Method with superpixel analysis has shown improved segmentation results in comparison to state-of-the-art methods.

Indexed as

Cervical cancercervical intraepithelial neoplasiaconvolutional neural networkdeep learningimage processingsegmentationsuperpixels

Identifiers

PMID29619277
PMCPMC5869967

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.