ArticleChemical science2015
Oxalyl amide assisted palladium-catalyzed synthesis of pyrrolidones
Article in Chemical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 113 citations in OpenAlex.
- Catalytic Functionalization of Unactivated π-Bonds Enabled by Bidentate Directing Auxiliaries.Angewandte Chemie (International ed. in English) · 2026Review
- Single-Electron-Transfer-Mediated Carbonylation Reactions.Accounts of chemical research · 2025Article
- Sustainable Synthesis of Medicinally Important Heterocycles.Mini reviews in medicinal chemistry · 2025Review
- Transition-Metal-Catalyzed Annulations Involving the Activation of C(spAngewandte Chemie (International ed. in English) · 2022Review
- Transition-Metal-Catalyzed, Coordination-Assisted Functionalization of Nonactivated C(spChemical reviews · 2021Review
- Synthesis of Cyclic Anhydrides via Ligand-Enabled C-H Carbonylation of Simple Aliphatic Acids.Angewandte Chemie (International ed. in English) · 2021Article
- Isoindolinone Synthesis via One-Pot Type Transition Metal Catalyzed C-C Bond Forming Reactions.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Review
- Diverse strategies for transition metal catalyzed distal C(spChemical science · 2020Review
- Pd(II)-Catalyzed Enantioselective γ-C(spJournal of the American Chemical Society · 2020Article
- Hemilabile Benzyl Ether Enables γ-C(spJournal of the American Chemical Society · 2019Article
- Diastereoselective C-H carbonylative annulation of aliphatic amines: a rapid route to functionalized γ-lactams.Chemical science · 2018Article
- A comprehensive overview of directing groups applied in metal-catalysed C-H functionalisation chemistry.Chemical Society reviews · 2018Review
- Computational study on palladium-catalyzed alkenylation of remote δ-C(spRSC advances · 2018Article
- Palladium-Catalyzed Transformations of Alkyl C-H Bonds.Chemical reviews · 2017Article
- Aminoquinoline-directed, cobalt-catalyzed carbonylation of sulfonamide spChemical communications (Cambridge, England) · 2017Article
- Cobalt-catalysed C-H carbonylative cyclisation of aliphatic amides.Chemical science · 2017Article
- Cobalt catalyzed carbonylation of unactivated C(spChemical science · 2017Article
- Stereoselective alkoxycarbonylation of unactivated C(sp3)-H bonds with alkyl chloroformates via Pd(II)/Pd(IV) catalysis.Nature communications · 2016Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The first Pd-catalyzed regioselective γ-carbonylation of oxalyl amide protected aliphatic amines with carbon monoxide leading to synthesis of pyrrolidones has been developed. Both γ-methyl and cyclopropyl methylene C-H bonds are well activated to obtain the corresponding pyrrolidones in moderate to excellent yields. The role of 3-(trifluoromethyl)benzoic acid as an additive is critical as it helps in stabilizing the palladium intermediate formed during the catalytic cycle. The reaction scope is extended to benzylamine and allyl amine derivatives, thereby affording the corresponding products in good to excellent yields.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.