Evidence map›Paper›PMID 29619162›Full record

ArticleMolecular autism2018

CRISPR/Cas9-induced

Chun-Xue Liu, Chun-Yang Li, Chun-Chun Hu, Yi Wang, Jia Lin, Yong-Hui Jiang, Qiang Li, Xiu Xu

Open access · goldAbstract read
In one paragraph

Article in Molecular autism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 159 citations in OpenAlex.

  1. Article
  2. Zebrafish frk Gene Knockout Shows Social Impairments Relevant to Autism and Delays Brain Development by Increasing Cell Proliferation.Autism research : official journal of the International Society for Autism Research · 2026
    Article
  3. Article
  4. Role and Impact of theInternational journal of molecular sciences · 2026
    Article
  5. Review
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  12. Article
  13. Establishment and characterization of adap1-deficient zebrafish.Development, growth & differentiation · 2025
    Article
  14. Review
  15. Knockout of theZoological research · 2025
    Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Chun-Xue Liu1Division of Child Health Care, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102 China.
Chun-Yang Li1Division of Child Health Care, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102 China.
Chun-Chun Hu1Division of Child Health Care, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102 China.
Yi Wang1Division of Child Health Care, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102 China.
Jia Lin2Center for Translational Medicine, Institute of Pediatrics, Shanghai Key Laboratory of Birth Defect, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102 China.
Yong-Hui Jiang3Department of Pediatrics and Neurobiology, Duke University School of Medicine, Durham, NC 27614 USA.
Qiang Li2Center for Translational Medicine, Institute of Pediatrics, Shanghai Key Laboratory of Birth Defect, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102 China.
Xiu Xu1Division of Child Health Care, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102 China.
Children's Hospital of Fudan University · CNDuke University · US

Funding

Analysis of Shank3 Complete and Temporal and Spatial Specific Knockout MiceR01MH098114 · NIMH · DUKE UNIVERSITY · PI JIANG, YONG-HUI · 2012 to 2016
$2.2M
A novel neural circuit analysis paradigm to model autism in miceR21MH104316 · NIMH · DUKE UNIVERSITY · PI JIANG, YONG-HUI · 2014 to 2015
$435k
A novel paradigm to dissect the function connectivity in Shank3 autism modelR21HD087795 · NICHD · YALE UNIVERSITY · PI JIANG, YONG-HUI · 2017 to 2018
$434k
NICHD NIH HHS R21 HD087795NIMH NIH HHS R01 MH098114NIMH NIH HHS R21 MH104316
6 · The paper itself

Abstract

Background: Human genetic and genomic studies have supported a strong causal role of Methods: CRISPR/Cas9 was applied to generate a Results: Conclusions: We generated the first inheritable

Indexed as

CRISPR-Cas SystemsDisease Models, AnimalAnimalsAutistic DisorderHomer Scaffolding ProteinsLocomotionMutationNerve Tissue ProteinsSocial BehaviorSynaptophysinZebrafishZebrafish ProteinsHomer Scaffolding ProteinsNerve Tissue ProteinsSHANK3 protein, zebrafishSynaptophysinZebrafish ProteinsAnimal modelASDCRISPR/Cas9shank3Social behaviorZebrafish

Identifiers

PMID29619162
PMCPMC5879542
OpenAlexW2802680397

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.