ArticleECS transactions2017
Proper Controls to Electrochemically Evaluate Carotenoids using β-Cyclodextrin Modified Surfaces.
Article in ECS transactions, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Nanostructured Cyclodextrin-Mediated Surface for Capacitive Determination of Cortisol in Multiple Biofluids.ACS applied materials & interfaces · 2022Article
- Reusable Cyclodextrin-Based Electrochemical Platform for Detection of trans-Resveratrol.ACS applied polymer materials · 2020Article
- Reorientation of Polymers in an Applied Electric Field for Electrochemical Sensors.Journal of the Electrochemical Society · 2020Article
- Guide to Selecting a Biorecognition Element for Biosensors.Bioconjugate chemistry · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We initially tested the electrochemical activity of beta-carotene and lutein at unmodified glassy carbon electrodes. We found good sensitivity (1 nA/μM) at high, micromolar concentrations, but serum levels are at nanomolar concentrations. To enhance the electrochemical activity, we modified the sensor surface with β-cyclodextrin, which has a hydrophobic core. Our goal was that the beta-carotene will be attracted to the β-cyclodextrin core, increasing surface interaction and sensitivity. Instead we saw a decrease in electrochemical activity. Further investigation with a methylene blue mediator indicated two results. First, it is unlikely the beta-carotene strongly interacts with the β-cyclodextrin surface. And, second, the presence of a co-solvent or surfactant can greatly disrupt the surface β-cyclodextrin activity.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.