ArticleJournal of occupational medicine and toxicology (London, England)2018
In vitro toxicological evaluation of surgical smoke from human tissue.
Article in Journal of occupational medicine and toxicology (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 53 citations in OpenAlex.
- Surgical smoke and its components, effects, and mitigation: a contemporary review.Toxicological sciences : an official journal of the Society of Toxicology · 2024Review
- Surgical smoke: a matter of hygiene, toxicology, and occupational health.GMS hygiene and infection control · 2024Review
- Do we need to reduce surgical smoke?Annals of translational medicine · 2022Article
- Impact of Surgical Smoke on the Surgical Team and Operating Room Nurses and Its Reduction Strategies: A Systematic Review.Iranian journal of public health · 2022Review
- Detection of human coronavirus RNA in surgical smoke generated by surgical devices.The Journal of hospital infection · 2021Article
- A study to quantify surgical plume and survey the efficiency of different local exhaust ventilations.Scientific reports · 2021Article
- Chemical composition of surgical smoke produced during the loop electrosurgical excision procedure when treating cervical intraepithelial neoplasia.World journal of surgical oncology · 2021Article
- Comparison of Surgical Smoke Generated During Electrosurgery with Aerosolized Particulates from Ultrasonic and High-Speed Cutting.Annals of biomedical engineering · 2021Article
- Gastroenterology Procedures Generate Aerosols: An Air Quality Turnover Solution to Mitigate COVID-19's Propagation Risk.International journal of environmental research and public health · 2020Article
- Surgical smoke and the anesthesia provider.Journal of anesthesia · 2020Review
- A Systems Approach to Assess Transport and Diffusion of Hazardous Airborne Particles in a Large Surgical Suite: Potential Impacts on Viral Airborne Transmission.International journal of environmental research and public health · 2020Article
- Analysis of electrocautery smoke released from the tissues frequently cut in orthopedic surgeries.World journal of orthopedics · 2020Article
- Particle and Carbon Dioxide Concentration Levels in a Surgical Room Conditioned with a Window/Wall Air-conditioning System.International journal of environmental research and public health · 2020Article
- Surgical Smoke-Hazard Perceptions and Protective Measures in German Operating Rooms.International journal of environmental research and public health · 2020Article
- Descriptive review of junior OB/GYN physicians' work task financial compensation in German hospitals.Journal of occupational medicine and toxicology (London, England) · 2019Review
- Awareness of surgical smoke hazards and enhancement of surgical smoke prevention among the gynecologists.Journal of Cancer · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOperating room personnel have the potential to be exposed to surgical smoke, the by-product of using electrocautery or laser surgical device, on a daily basis. Surgical smoke is made up of both biological by-products and chemical pollutants that have been shown to cause eye, skin and pulmonary irritation.
methodsIn this study, surgical smoke was collected in real time in cell culture media by using an electrocautery surgical device to cut and coagulate human breast tissues. Airborne particle number concentration and particle distribution were determined by direct reading instruments. Airborne concentration of selected volatile organic compounds (VOCs) were determined by evacuated canisters. Head space analysis was conducted to quantify dissolved VOCs in cell culture medium. Human small airway epithelial cells (SAEC) and RAW 264.7 mouse macrophages (RAW) were exposed to surgical smoke in culture media for 24 h and then assayed for cell viability, lactate dehydrogenase (LDH) and superoxide production.
resultsOur results demonstrated that surgical smoke-generated from human breast tissues induced cytotoxicity and LDH increases in both the SAEC and RAW. However, surgical smoke did not induce superoxide production in the SAEC or RAW.
conclusionThese data suggest that the surgical smoke is cytotoxic in vitro and support the previously published data that the surgical smoke may be an occupational hazard to healthcare workers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.