Evidence map›Paper›PMID 29619070›Full record

ReviewEvidence-based complementary and alternative medicine : eCAM2018

Use of Jianpi Jiedu Herbs in Patients with Advanced Colorectal Cancer: A Systematic Review and Meta-Analysis.

Shaofan Zhang, Li Shi, Dan Mao, Weijun Peng, Chenxia Sheng, Chenchen Ding, Fengxia Lin, Caiyun Lei, Sifang Zhang

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Evidence-based complementary and alternative medicine : eCAM, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

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  12. Meta-Analysis of Xihuang Pill Efficacy When Combined with Chemotherapy for Treatment of Breast Cancer.Evidence-based complementary and alternative medicine : eCAM · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Shaofan ZhangDepartment of Integrated Chinese and Western Medicine, The Second Hospital of Xiangya, Central South University, Changsha 410008, China.ORCID 0000-0002-3892-0027
Li ShiDepartment of Integrated Chinese and Western Medicine, The Second Hospital of Xiangya, Central South University, Changsha 410008, China.
Dan MaoDepartment of Integrated Chinese and Western Medicine, The Second Hospital of Xiangya, Central South University, Changsha 410008, China.
Weijun PengDepartment of Integrated Chinese and Western Medicine, The Second Hospital of Xiangya, Central South University, Changsha 410008, China.ORCID 0000-0002-4506-0942
Chenxia ShengDepartment of Integrated Chinese and Western Medicine, The Second Hospital of Xiangya, Central South University, Changsha 410008, China.ORCID 0000-0002-9006-6120
Chenchen DingDepartment of Integrated Chinese and Western Medicine, The Second Hospital of Xiangya, Central South University, Changsha 410008, China.
Fengxia LinDepartment of Cardiology, Affiliated Bao'an TCM Hospital, Guangzhou University of Traditional Chinese Medicine, Shenzhen, Guangdong, China.
Caiyun LeiDepartment of Integrated Chinese and Western Medicine, The Second Hospital of Xiangya, Central South University, Changsha 410008, China.
Sifang ZhangDepartment of Integrated Chinese and Western Medicine, The Second Hospital of Xiangya, Central South University, Changsha 410008, China.ORCID 0000-0002-6540-1855
Central South University · CNGuangzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo systematically review the effect of invigorating Pi and detoxification (Jianpi Jiedu, (JPJD)) herbs in advanced colorectal cancer (CRC) patients receiving chemotherapy.

methodsThree English and four Chinese databases were searched. Literature was screened by EndNote X7 and data were analyzed by RevMan 5.2.

resultsThis review comprised 12 randomized clinical studies of 701 patients. The results showed that JPJD herbs improved the therapeutic effect on Chinese medicine symptoms [risk ratio (RR) = 1.59; 95% confidence interval (CI): 1.35~1.88] and Karnofsky performance score [RR = 2.07; 95% CI: 1.52~2.82] for advanced CRC patients receiving chemotherapy, lowered the Chinese medicine symptoms' score [weighted mean difference = -2.44; 95% CI: -3.23~-1.64], reduced the incidence of nausea and vomiting [RR = 0.23; 95% CI: 0.11~0.49], improved platelet at toxicity grades III-IV [odds ratio = 0.29; 95% CI: 0.12~0.74] and I-IV [RR = 0.65; 95% CI: 0.51~0.82], and improved white blood cell at toxicity grades III-IV [RR = 0.37; 95% CI: 0.23~0.58] and I-IV [RR = 0.69; 95% CI: 0.60~0.79]. However, the results showed no significant effect on tumor response.

conclusionJPJD herbs can improve quality of life, relieve symptoms, and reduce adverse events of advanced CRC patients receiving chemotherapy.

Identifiers

PMID29619070
PMCPMC5830191
OpenAlexW2785496368

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.