Evidence map›Paper›PMID 29619056›Full record

ArticleJournal of contemporary brachytherapy2018

Should molecular subtype be recommended as one of the selection criteria for accelerated partial breast irradiation? Preliminary results from an Asian cohort.

Tabassum Wadasadawala, Monidipa Mondal, Siji Nojin Paul, Vani Parmar, Nita Nair, Tanuja Shet, Sangeeta Desai, Sudeep Gupta, Rajiv Sarin

Abstract read
In one paragraph

Article in Journal of contemporary brachytherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tabassum WadasadawalaDepartment of Radiation Oncology, Advanced Centre for Treatment, Research & Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Kharghar, Navi Mumbai.
Monidipa MondalDepartment of Radiation Oncology, Tata Memorial Hospital (TMH), Parel, Mumbai.
Siji Nojin PaulDepartment of Radiation Oncology (Medical Physics), ACTREC, TMC, Kharghar, Navi Mumbai.
Vani ParmarDepartment of Surgical Oncology, ACTREC, TMC, Kharghar, Navi Mumbai.
Nita NairDepartment of Surgical Oncology, TMH, Parel, Mumbai.
Tanuja ShetDepartment of Pathology, TMH, Parel, Mumbai.
Sangeeta DesaiDepartment of Pathology, TMH, Parel, Mumbai.
Sudeep GuptaDepartment of Medical Oncology, ACTREC,TMC, Kharghar, Navi Mumbai, India.
Rajiv SarinDepartment of Radiation Oncology, Tata Memorial Hospital (TMH), Parel, Mumbai.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of this study was to report clinical outcomes in patients treated with accelerated partial breast irradiation (APBI), stratified as per molecular subtype and American Society for Therapeutic Radiology and Oncology/Groupe Européen de Curiethérapie and European Society for Radiotherapy & Oncology (ASTRO/GEC-ESTRO) patient selection criteria in order to determine whether molecular subtype should be recommended as one of the selection criteria for APBI. MATERIAL AND

methods157 early-stage breast cancers patients, treated with APBI using multi-catheter interstitial brachytherapy with ≥ 6 months follow-up were included. Molecular subtype was assigned based on estrogen/progesterone receptor (ER/PR), Her2neu and tumor grade. Patients were stratified into ASTRO and GEC-ESTRO risk groups, as per updated ASTRO consensus statement (CS) and GEC-ESTRO recommendation, respectively. The Kaplan-Meier method was used to calculate the time to event data of clinical outcomes.

resultsWith a median follow-up of 35 months, local control (LC) and locoregional control (LRC) were not significantly different among the different molecular subtypes (

conclusionsNone of the mentioned APBI guidelines predicted local or locoregional recurrence risk in our study population. Additional follow-up will be needed to recommend inclusion of molecular subtype (or at least HER2 receptor status) in the patient selection criteria for APBI.

Indexed as

accelerated partial breast irradiationbreast cancermulticatheter interstitial brachytherapy

Identifiers

PMID29619056
PMCPMC5881594

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.