Evidence map›Paper›PMID 29619055›Full record

ArticleJournal of contemporary brachytherapy2018

Late G2 vagina toxicity in post-operative endometrial carcinoma is associated with a 68 Gy dose equivalent to 2 Gy per fraction

María Del Valle Aguilera, Ángeles Rovirosa, Carlos Ascaso, Antonio Herreros, Joan Sánchez, Julia Garcia-Migue, Stephanía Cortes, Eduardo Agusti, Cristina Camacho, Yaowen Zhang and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of contemporary brachytherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Consensus and recommendations on vaginal-cuff Brachytherapy of the Spanish Brachytherapy Groups of SEOR and SEFM.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021
    Guideline
  2. D90 and DCancers · 2026
    Article
  3. Review
  4. Article
  5. Impact of Vaginal Dilator Use and 68 Gy EQD2Journal of personalized medicine · 2024
    Article
  6. Vaginal dilator use more than 9 months is a main prognostic factor for reducing G2‑late vaginal complications in 3D‑vaginal‑cuff brachytherapy (interventional radiotherapy)?Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Article
  7. Article
  8. Preliminary results of a vaginal constraint for reducing G2 late vaginal complications after postoperative brachytherapy in endometrial cancer: a prospective analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022
    Article
  9. Article
  10. Article
  11. Is one brachytherapy fraction of 7 Gy similar to more fractions after external beam irradiation in postoperative endometrial carcinoma?Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2020
    Article
  12. Article
  13. Postoperative endometrial carcinoma treated with external beam irradiation plus vaginal-cuff brachytherapy. Is there a dose relationship with G2 vaginal complications?Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

María Del Valle AguileraRadiation Oncology Department, Hospital Clinic Universitari, Barcelona, Spain.
Ángeles RovirosaRadiation Oncology Department, Hospital Clinic Universitari, Barcelona, Spain.
Carlos AscasoClinical Basics Department, Medicine Faculty, Universitat de Barcelona, Instituto de Investigaciones Biomédicas Augusto Pi i Sunyer, Barcelona, Spain.
Antonio HerrerosRadiation Oncology Department, Hospital Clinic Universitari, Barcelona, Spain.
Joan SánchezEconomics Department, Hospital Clinic Universitari, Barcelona, Spain.
Julia Garcia-MigueRadiation Oncology Department, Hospital Clinic Universitari, Barcelona, Spain.
Stephanía CortesRadiation Oncology Department, Hospital Clinic Universitari, Barcelona, Spain.
Eduardo AgustiRadiation Oncology Department, Hospital Clinic Universitari, Barcelona, Spain.
Cristina CamachoRadiation Oncology Department, Hospital Clinic Universitari, Barcelona, Spain.
Yaowen ZhangRadiation Oncology Department, Hospital Clinic Universitari, Barcelona, Spain.
Yan LiRadiation Oncology Department, Hospital Clinic Universitari, Barcelona, Spain.
Sebastià SabaterRadiation Oncology Department, Hospital Universitario de Albacete, Albacete, Spain.
Aureli TorneGynecological Cancer Unit, Hospital Clinic Universitari, Barcelona, Spain.
Meritxell ArenasRadiation Oncology Department, Hospital Universitari Sant Joan de Reus, Reus, Spain.
Hospital Universitari de Vic · ESHospital General Universitario de Albacete · ESHospital Universitari Sant Joan de Reus · ESUniversitat de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate if the dose equivalent to 2 Gy per fraction (EQD2) MATERIAL AND

methodsFrom June 2014 till November 2015, 67 consecutive P-EC patients underwent VBT ± EBRT; 44 patients received EBRT (median, 45 Gy; range, 44-50.4) + VBT (7 Gy), and 23 exclusive-VBT (6 Gy x 3 fractions). The upper 2.5 cm of vagina was delineated on computed tomography (CT). The active-length source was 2.5 cm, and the brachytherapy dose was prescribed at 5 mm from the applicator. D

resultsThe mean follow-up was 23.2 months (7.6-46.8). Median D90 was 7.8 Gy

conclusionsMore than 68 Gy EQD2

Indexed as

endometrial cancergynecologylate vaginal toxicityvaginal-cuff

Identifiers

PMID29619055
PMCPMC5881596
OpenAlexW2791215513

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.