Evidence map›Paper›PMID 29619004›Full record

ArticleFrontiers in neurology2018

Protection of Oligodendrocytes Through Neuronal Overexpression of the Small GTPase Ras in Hyperoxia-Induced Neonatal Brain Injury.

Meray Serdar, Josephine Herz, Karina Kempe, Elke Winterhager, Holger Jastrow, Rolf Heumann, Ursula Felderhoff-Müser, Ivo Bendix

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Genes · 2024
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Neonatal hyperoxia induces gut dysbiosis and behavioral changes in adolescent mice.Journal of the Chinese Medical Association : JCMA · 2021
    Article
  14. Article
  15. Article
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Meray SerdarDepartment of Pediatrics I, Neonatology, University Hospital, University Duisburg-Essen, Essen, Germany.
Josephine HerzDepartment of Pediatrics I, Neonatology, University Hospital, University Duisburg-Essen, Essen, Germany.
Karina KempeDepartment of Pediatrics I, Neonatology, University Hospital, University Duisburg-Essen, Essen, Germany.
Elke WinterhagerImaging Center Essen, EM Unit, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Holger JastrowImaging Center Essen, EM Unit, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Rolf HeumannBiochemistry II, Molecular Neurobiochemistry, Faculty of Chemistry and Biochemistry, Ruhr University Bochum, Bochum, Germany.
Ursula Felderhoff-MüserDepartment of Pediatrics I, Neonatology, University Hospital, University Duisburg-Essen, Essen, Germany.
Ivo BendixDepartment of Pediatrics I, Neonatology, University Hospital, University Duisburg-Essen, Essen, Germany.
University of Duisburg-Essen · DEEssen University Hospital · DERuhr University Bochum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prematurely born infants are highly susceptible to various environmental factors, such as inflammation, drug exposure, and also high environmental oxygen concentrations. Hyperoxia induces perinatal brain injury affecting white and gray matter development. It is well known that mitogen-activated protein kinase signaling is involved in cell survival, proliferation, and differentiation. Therefore, we aim to elucidate cell-specific responses of neuronal overexpression of the small GTPase Ras on hyperoxia-mediated brain injury. Six-day-old (P6)

Indexed as

brain injuryhyperoxianeuronal Rasneuroprotectionpreterm birthwhite matter injury

Identifiers

PMID29619004
PMCPMC5871665
OpenAlexW2789626792

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.