ArticleClinical and molecular allergy : CMA2018
Role of genetic variations of
Article in Clinical and molecular allergy : CMA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 8 citations in OpenAlex.
- Chitinase 3 like 1 suppresses the stability and activity of p53 to promote lung tumorigenesis.Cell communication and signaling : CCS · 2020Article
- Systemic Immune Modulation in Gliomas: Prognostic Value of Plasma IL-6, YKL-40, and Genetic Variation in YKL-40.Frontiers in oncology · 2020Article
- Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma.Allergy, asthma & immunology research · 2019Review
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Authors and funding
4 authors at 2 institutions in 1 country.
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Abstract
backgroundSingle nucleotide polymorphisms (SNPs) in
methodsTo address the role of these genetic variations, 390 patients with well-controlled bronchial asthma and living in Japan were recruited, genotyped, and had a pulmonary function test performed on them in this study. To analyze the concentration levels of CHI3L1 protein, bronchial lavage fluids were examined.
resultsForced expiratory volume in one second, %predicted (%FEV1), was significantly decreased in homozygotes of rs1214194 compared to heterozygotes and wild type. The age of onset of adult bronchial asthma was significantly younger in GG homozygotes of rs4950928 and AA homozygotes of rs1214194 than in the other two genotypes. The concentration of CHI3L1 protein in bronchial lavage fluid increased in both homozygotes of rs4950928 and rs1214194.
conclusionsOur study demonstrated that the homozygotes of rs4950928 and rs1214194 of
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